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The sham effect of invasive interventions in chronic coronary syndromes: a systematic review and meta-analysis

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dc.contributor.authorPalma, Catarina
dc.contributor.authorDavid, Cláudio
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorCosta, João
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorCaldeira, Daniel
dc.date.accessioned2022-06-23T16:48:09Z
dc.date.available2022-06-23T16:48:09Z
dc.date.issued2022
dc.description© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.pt_PT
dc.description.abstractBackground: Some patients with chronic coronary syndromes undergo invasive procedures but the efficacy of such interventions remains to be robustly established by randomised sham-controlled trials (RCTs). Purpose: To determine the sham effect in patients with chronic coronary syndromes enrolled in RCTs by performing a systematic review and meta-analysis. Methods: In April 2022, we performed a literature search for published patient-blind RCTs (CENTRAL, MEDLINE®, PsycINFO, and reference lists) with sham procedures, reporting the pre-post effects in the invasive sham arm among patients with Canadian cardiovascular society (CCS) angina or angina equivalents. Results: 16 RCTs were included with 546 patients in the sham arm. Pooled results showed that sham interventions were associated with: improvement of 7% (95% CI 2-11%; I2 = 0%) in exercise time; decrease of 0.78 (95% CI - 1.10 to - 0.47; I2 = 75%) in CCS angina class; decrease of 53% (95% CI 24-71%; I2 = 96%) and 25% (95% CI 20-29%; I2 = 0%) in anginal episodes and nitroglycerine (NTG) use, respectively. Pooled results also showed an improvement in the physical functioning, angina frequency, treatment satisfaction, and disease perception domains of the Seattle Angina Questionnaire (SAQ). Conclusion: Sham interventions in patients with chronic coronary syndromes were associated with a significant decrease in anginal episodes, NTG use, and CCS angina class and increased SAQ quality of life and exercise time. These results highlight the need for previous non sham-controlled trials to be interpreted with caution, and the importance of new invasive interventions to be evaluated versus a sham procedure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Cardiovasc Disord. 2022 May 14;22(1):223pt_PT
dc.identifier.doi10.1186/s12872-022-02658-xpt_PT
dc.identifier.eissn1471-2261
dc.identifier.urihttp://hdl.handle.net/10451/53464
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://bmccardiovascdisord.biomedcentral.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChronic coronary syndromespt_PT
dc.subjectInvasive treatmentpt_PT
dc.subjectSham effectpt_PT
dc.subjectSham procedurept_PT
dc.titleThe sham effect of invasive interventions in chronic coronary syndromes: a systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Cardiovascular Disorderspt_PT
oaire.citation.volume22pt_PT
person.familyNameAntunes David
person.familyNameFernandes
person.familyNamePinto
person.familyNameCosta
person.familyNameFerreira
person.familyNameCaldeira
person.givenNameCláudio Virgílio
person.givenNameRicardo
person.givenNameFausto J.
person.givenNameJoão
person.givenNameJoaquim J
person.givenNameDaniel
person.identifier309018
person.identifier1308889
person.identifier480560
person.identifier1624753
person.identifier.ciencia-id0C16-4DE0-15E7
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.ciencia-idAA19-EC35-8D01
person.identifier.orcid0000-0002-8749-8598
person.identifier.orcid0000-0002-7253-6475
person.identifier.orcid0000-0002-8034-4529
person.identifier.orcid0000-0002-5831-4921
person.identifier.orcid0000-0003-3950-5113
person.identifier.orcid0000-0002-2520-5673
person.identifier.ridC-7501-2015
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id24436565500
person.identifier.scopus-author-id7102740158
person.identifier.scopus-author-id55499748300
person.identifier.scopus-author-id7403252466
person.identifier.scopus-author-id36623384200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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