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Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia

2019Artigo científico Acesso aberto
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dc.contributor.authorRittman, Timothy
dc.contributor.authorBorchert, Robin
dc.contributor.authorJones, Simon
dc.contributor.authorvan Swieten, John
dc.contributor.authorBorroni, Barbara
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorMasellis, Mario
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorGraff, Caroline
dc.contributor.authorTagliavini, Fabrizio
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorSantiago, Beatriz
dc.contributor.authorScarpini, Elio
dc.contributor.authorSchönecker, Sonja
dc.contributor.authorSemler, Elisa
dc.contributor.authorShafei, Rachelle
dc.contributor.authorShoesmith, Christen
dc.contributor.authorTábuas-Pereira, Miguel
dc.contributor.authorTainta, Mikel
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorTang-Wai, David
dc.contributor.authorLaforce, Robert
dc.contributor.authorThomas, David L.
dc.contributor.authorThonberg, Hakan
dc.contributor.authorTimberlake, Carolyn
dc.contributor.authorTiraboschi, Pietro
dc.contributor.authorVandamme, Philip
dc.contributor.authorVandenbulcke, Mathieu
dc.contributor.authorVeldsman, Michele
dc.contributor.authorVerdelho, Ana
dc.contributor.authorVillanua, Jorge
dc.contributor.authorWarren, Jason
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorWilke, Carlo
dc.contributor.authorWoollacott, Ione
dc.contributor.authorWlasich, Elisabeth
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorZulaica, Miren
dc.contributor.authorDe Mendonça, Alexandre
dc.contributor.authorSorbi, Sandro
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorRowe, James B.
dc.contributor.authorAfonso, Sónia
dc.contributor.authorAlmeida, Maria Rosario
dc.contributor.authorAnderl-Straub, Sarah
dc.contributor.authorAndersson, Christin
dc.contributor.authorAntonell, Anna
dc.contributor.authorArchetti, Silvana
dc.contributor.authorArighi, Andrea
dc.contributor.authorBalasa, Mircea
dc.contributor.authorBarandiaran, Myriam
dc.contributor.authorBargalló, Nuria
dc.contributor.authorBartha, Robart
dc.contributor.authorBender, Benjamin
dc.contributor.authorBenussi, Luisa
dc.contributor.authorBessi, Valentina
dc.contributor.authorBinetti, Giuliano
dc.contributor.authorBlack, Sandra
dc.contributor.authorBocchetta, Martina
dc.contributor.authorBorrego-Ecija, Sergi
dc.contributor.authorBras, Jose
dc.contributor.authorBruffaerts, Rose
dc.contributor.authorCaroppo, Paola
dc.contributor.authorCash, David
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorConvery, Rhian
dc.contributor.authorCope, Thomas
dc.contributor.authorCosseddu, Maura
dc.contributor.authorde Arriba, María
dc.contributor.authorDi Fede, Giuseppe
dc.contributor.authorDíaz, Zigor
dc.contributor.authorDick, Katrina M.
dc.contributor.authorDuro, Diana
dc.contributor.authorFenoglio, Chiara
dc.contributor.authorFerrari, Camilla
dc.contributor.authorFerreira, Catarina B.
dc.contributor.authorFlanagana, Toby
dc.contributor.authorFox, Nick
dc.contributor.authorFreedman, Morris
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorGabilondo, Alazne
dc.contributor.authorGasparotti, Roberto
dc.contributor.authorGauthier, Serge
dc.contributor.authorGazzina, Stefano
dc.contributor.authorGhidoni, Roberta
dc.contributor.authorGiaccone, Giorgio
dc.contributor.authorGorostidi, Ana
dc.contributor.authorGreaves, Caroline
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorHeller, Carolin
dc.contributor.authorHoegen, Tobias
dc.contributor.authorIndakoetxea, Begoña
dc.contributor.authorJelic, Vesna
dc.contributor.authorJiskoot, Lize
dc.contributor.authorKarnath, Hans-Otto
dc.contributor.authorKeren, Ron
dc.contributor.authorLeitão, Maria João
dc.contributor.authorLladó, Albert
dc.contributor.authorLombardi, Gemma
dc.contributor.authorLoosli, Sandra
dc.contributor.authorMaruta, Carolina
dc.contributor.authorMead, Simon
dc.contributor.authorMeeter, Lieke
dc.contributor.authorMiltenberger-Miltenyi, Gabriel
dc.contributor.authorvan Minkelen, Rick
dc.contributor.authorMitchell, Sara
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorNeason, Mollie
dc.contributor.authorNicholas, Jennifer
dc.contributor.authorÖijerstedt, Linn
dc.contributor.authorOlives, Jaume
dc.contributor.authorPadovani, Alessandro
dc.contributor.authorPanman, Jessica
dc.contributor.authorPapma, Janne
dc.contributor.authorPievani, Michela
dc.contributor.authorPijnenburg, Yolande
dc.contributor.authorPremi, Enrico
dc.contributor.authorPrioni, Sara
dc.contributor.authorPrix, Catharina
dc.contributor.authorRademakers, Rosa
dc.contributor.authorRedaelli, Veronica
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorRosa-Neto, Pedro
dc.contributor.authorRossi, Giacomina
dc.contributor.authorRosser, Martin
dc.date.accessioned2022-05-09T11:41:06Z
dc.date.available2022-05-09T11:41:06Z
dc.date.issued2019
dc.description© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)pt_PT
dc.description.abstractThe presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despite loss of both brain volume and functional connections, there is maintenance of an efficient topological organization of the brain's functional network in the years leading up to the estimated age of frontotemporal dementia symptom onset. After this point, functional network efficiency declines markedly. Reduction in connectedness was most marked in highly connected hub regions. Measures of topological efficiency of the brain's functional network and organization predicted cognitive dysfunction in domains related to symptomatic frontotemporal dementia and connectivity correlated with brain volume loss in frontotemporal dementia. We propose that maintaining the efficient organization of the brain's functional network supports cognitive health even as atrophy and connectivity decline presymptomatically.pt_PT
dc.description.sponsorshipThis work was funded by the UK Medical Research Council, the Italian Ministry of Health, and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant [grant number CoEN015]. JBR was supported by the Wellcome Trust [grant number 103838]. JBR, RB, TR, and SJ were supported by the NIHR Cambridge Biomedical Research Centre and Medical Research Council [grant number G1100464]. The Dementia Research Centre at UCL is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation, NIHR Queen Square Dementia Biomedical Research Unit, NIHR UCL/H Biomedical Research Centre and Dementia Platforms UK. JDR is supported by an MRC Clinician Scientist Fellowship [grant number MR/M008525/1] and has received funding from the NIHR Rare Disease Translational Research Collaboration [grant number BRC149/NS/MH]. MM is supported by the Canadian Institutes of Health Research, Department of Medicine at Sunnybrook Health Sciences Centre and the University of Toronto, and the Sunnybrook Research Institute. RL is supported by Réseau de médecine génétique appliquée, Fonds de recherche du Québec—Santé [grant number FRQS]. FT is supported by the Italian Ministry of Health. DG is supported by the Fondazione Monzino and Italian Ministry of Health, Ricerca Corrente. SS is supported by Cassa di Risparmio di Firenze [grant number CRF 2013/0199] and the Ministry of Health [grant number RF-2010-2319722]. JvS is supported by The Netherlands Organisation for Health Research and Development Memorable grant [grant number 733050103] and Netherlands Alzheimer Foundation Memorable grant [grant number 733050103].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurobiol Aging. 2019 May;77:169-177pt_PT
dc.identifier.doi10.1016/j.neurobiolaging.2018.12.009pt_PT
dc.identifier.eissn1558-1497
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/10451/52792
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neurobiology-of-agingpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCognitionpt_PT
dc.subjectConnectivitypt_PT
dc.subjectFrontotemporal dementiapt_PT
dc.subjectFunctional imagingpt_PT
dc.subjectGeneticspt_PT
dc.titleFunctional network resilience to pathology in presymptomatic genetic frontotemporal dementiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage177pt_PT
oaire.citation.startPage169pt_PT
oaire.citation.titleNeurobiology of Agingpt_PT
oaire.citation.volume77pt_PT
person.familyNameVerdelho
person.familyNamede Mendonça
person.familyNameMaruta
person.familyNameMiltenberger-Miltenyi
person.givenNameAna
person.givenNameAlexandre
person.givenNameCarolina
person.givenNameGabriel
person.identifier.ciencia-idFC14-938F-EBBD
person.identifier.ciencia-id1615-41B4-0848
person.identifier.ciencia-id4B1D-5F59-6221
person.identifier.ciencia-idAE16-3A8D-0392
person.identifier.orcid0000-0003-4945-4946
person.identifier.orcid0000-0002-0488-1453
person.identifier.orcid0000-0003-3359-379X
person.identifier.orcid0000-0003-0224-1281
person.identifier.scopus-author-id6602902026
person.identifier.scopus-author-id7003320823
person.identifier.scopus-author-id35327513800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery53ca3547-99ce-4b68-9330-7879a54c47b7

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