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Endothelial cells on the move: dynamics in vascular morphogenesis and disease

2020Journal article Open access
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dc.contributor.authorFonseca, Catarina
dc.contributor.authorBarbacena, Pedro
dc.contributor.authorFranco, Claudio
dc.date.accessioned2021-07-28T14:03:39Z
dc.date.available2021-07-28T14:03:39Z
dc.date.issued2020
dc.description© 2020 The authors 2020. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.pt_PT
dc.description.abstractThe vascular system is a hierarchically organized network of blood vessels that play crucial roles in embryogenesis, homeostasis and disease. Blood vessels are built by endothelial cells - the cells lining the interior of blood vessels - through a process named vascular morphogenesis. Endothelial cells react to different biomechanical signals in their environment by adjusting their behavior to: (1) invade, proliferate and fuse to form new vessels (angiogenesis); (2) remodel, regress and establish a hierarchy in the network (patterning); and (3) maintain network stability (quiescence). Each step involves the coordination of endothelial cell differentiation, proliferation, polarity, migration, rearrangements and shape changes to ensure network integrity and an efficient barrier between blood and tissues. In this review, we highlighted the relevance and the mechanisms involving endothelial cell migration during different steps of vascular morphogenesis. We further present evidence on how impaired endothelial cell dynamics can contribute to pathology.pt_PT
dc.description.sponsorshipC A F was supported by European Research Council Starting Grant (AXIAL.EC; 679368), the Fundação para a Ciência e a Tecnologia funding (grants: IF/00412/2012; EXPL/BEX-BCM/2258/2013; PTDC/MED-PAT/31639/2017; PTDC/BIA-CEL/32180/2017), and a grant from the Fondation Leducq (17CVD03).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVasc Biol. 2020 Jul 2;2(1):H29-H43.pt_PT
dc.identifier.doi10.1530/VB-20-0007pt_PT
dc.identifier.eissn2516-5658
dc.identifier.urihttp://hdl.handle.net/10451/49188
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioscientifica Ltd.pt_PT
dc.relationDeregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy
dc.relationIdentify the mechanisms of endothelial tip cell invasive behavior in order to inhibit physiological and pathological sprouting angiogenesis
dc.relation.publisherversionhttps://vb.bioscientifica.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAngiogenesispt_PT
dc.subjectCell migrationpt_PT
dc.subjectCell polaritypt_PT
dc.subjectVascular diseasept_PT
dc.subjectVascular remodellingpt_PT
dc.titleEndothelial cells on the move: dynamics in vascular morphogenesis and diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDeregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy
oaire.awardTitleIdentify the mechanisms of endothelial tip cell invasive behavior in order to inhibit physiological and pathological sprouting angiogenesis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00412%2F2012%2FCP0163%2FCT0007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBEX-BCM%2F2258%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-PAT%2F31639%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-CEL%2F32180%2F2017/PT
oaire.citation.endPageH43pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPageH29pt_PT
oaire.citation.titleVascular Biologypt_PT
oaire.citation.volume2pt_PT
oaire.fundingStreamInvestigador FCT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameFonseca
person.familyNameBarbacena
person.familyNameFranco
person.givenNameCatarina
person.givenNamePedro
person.givenNameClaudio
person.identifierD-8117-2015
person.identifier.ciencia-idCB1D-8BC4-4226
person.identifier.ciencia-idF012-B7D6-AE72
person.identifier.orcid0000-0002-1978-0612
person.identifier.orcid0000-0001-6905-040X
person.identifier.orcid0000-0002-2861-3883
person.identifier.scopus-author-id24280736600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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