Publicação
γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer
| dc.contributor.author | Silva-Santos, Bruno | |
| dc.contributor.author | Mensurado, Sofia | |
| dc.contributor.author | Coffelt, Seth B. | |
| dc.date.accessioned | 2021-07-23T10:46:44Z | |
| dc.date.available | 2021-07-23T10:46:44Z | |
| dc.date.issued | 2019 | |
| dc.description | Copyright © 2019, The Publisher | pt_PT |
| dc.description.abstract | The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells. These are major attributes of γδ T cells, a lymphoid lineage that is often underestimated despite its major role in tumour immune surveillance, which has been established in a variety of preclinical cancer models. This situation notwithstanding, in particular instances the tumour microenvironment seemingly mobilizes γδ T cells with immunosuppressive or tumour-promoting functions, thus emphasizing the importance of regulating γδ T cell responses in order to realize their translation into effective cancer immunotherapies. In this Review we outline both seminal work and recent advances in our understanding of how γδ T cells participate in tumour immunity and how their functions are regulated in experimental models of cancer. We also discuss the current strategies aimed at maximizing the therapeutic potential of human γδ T cells, on the eve of their exploration in cancer clinical trials that may position them as key players in cancer immunotherapy. | pt_PT |
| dc.description.sponsorship | We acknowledge funding from the European Research Council (CoG_646701 to B.S.-S.), Cancer Research UK Glasgow Centre (A25142 to S.B.C.), Breast Cancer Now (2018JulPR1101 to S.B.C.), Wellcome Trust (208990/Z/17/Z to S.B.C.), Tenovus Scotland (Project S17-17 to S.B.C.) and Fundação para a Ciência e a Tecnologia / Ministério da Ciência, Tecnologia e Ensino Superior through Fundos do Orçamento de Estado (refs. UID/BIM/50005/2019 and PD/BD/114099/2015). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Nat Rev Cancer. 2019 Jul;19(7):392-404. | pt_PT |
| dc.identifier.doi | 10.1038/s41568-019-0153-5 | pt_PT |
| dc.identifier.eissn | 1474-1768 | |
| dc.identifier.issn | 1474-175X | |
| dc.identifier.uri | http://hdl.handle.net/10451/49076 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer Nature | pt_PT |
| dc.relation | MicroRNA determinants of the balance between effector and regulatory T cells in vivo | |
| dc.relation | Instituto de Medicina Molecular | |
| dc.relation | A designar | |
| dc.relation.publisherversion | https://www.nature.com/nrc/ | pt_PT |
| dc.title | γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | MicroRNA determinants of the balance between effector and regulatory T cells in vivo | |
| oaire.awardTitle | Instituto de Medicina Molecular | |
| oaire.awardTitle | A designar | |
| oaire.awardURI | info:eu-repo/grantAgreement/EC/H2020/646701/EU | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F50005%2F2019/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//PD%2FBD%2F114099%2F2015/PT | |
| oaire.citation.endPage | 404 | pt_PT |
| oaire.citation.issue | 7 | pt_PT |
| oaire.citation.startPage | 392 | pt_PT |
| oaire.citation.title | Nature Reviews Cancer | pt_PT |
| oaire.citation.volume | 19 | pt_PT |
| oaire.fundingStream | H2020 | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Silva-Santos | |
| person.familyName | Mensurado Santos | |
| person.givenName | Bruno | |
| person.givenName | Sofia | |
| person.identifier | https://scholar.google.com/citations?user=83kKWFAAAAAJ&hl=en&oi=ao | |
| person.identifier.ciencia-id | D51E-6517-BE6A | |
| person.identifier.ciencia-id | BA10-56F0-7CAD | |
| person.identifier.orcid | 0000-0003-4141-9302 | |
| person.identifier.orcid | 0000-0002-5157-0033 | |
| person.identifier.scopus-author-id | 6505885924 | |
| project.funder.identifier | http://doi.org/10.13039/501100008530 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | European Commission | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
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