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Estudo do prognóstico da lesão renal aguda no doente médico
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Resumo(s)
A lesão renal aguda (LRA) é considerada uma das complicações mais graves em indivíduos hospitalizados, com incidência na população internada estimada em 18,3%. Este estudo pretende analisar o impacto de diversos fatores clínicos e laboratoriais no prognóstico destes episódios a nível da função renal.
Realizou-se um estudo cohort retrospetivo no Hospital de Santa Maria, com 152 doentes. LRA foi definida de acordo com os critérios Kidney Disease; Improving Global Outcomes (KDIGO) e definiu-se sobrevivência renal de acordo com a recomendações de 2019 da UK Renal Association. O outcome primário foi a sobrevivência renal à data da alta e os secundários a sobrevivência renal 2 a 4 meses depois, mortalidade a 28 dias e necessidade de diálise de novo.
A pandemia se SARS-CoV-2 impediu o acesso aos edifícios do Centro Hospitalar Universitário Lisboa Norte, pelo que os dados recolhidos não são suficientes para alcançar a amostra mínima calculada. Planeia-se expandir a amostra para o valor previamente calculado, realizando-se, posteriormente, a análise estatística de inferência e a construção de um modelo preditivo do prognóstico com recurso à ferramenta WEKA, para mineração de dados. Não obstante, é apresentada a estatística descritiva da amostra já incluída e discutidas as reflexões sobre a mesma.
Acute kidney injury (AKI) is considered one of the most serious complications in hospitalized patients, with an incidence in the hospitalized individuals estimated at 18.3%. This study aims to analyze the impact of several clinical and laboratory data in the prognosis regarding kidney function. This was a retrospective cohort study carried at Hospital de Santa Maria, with 152 patients. AKI was defined according to Kidney Disease; Improving Global Outcomes (KDIGO) criteria and Kidney Recovery according to 2019 Guideline of the UK Renal Association. The primary outcome was kidney recovery at the time of discharge and the secondary outcomes were kidney recover 2 to 4 months later, 28-day mortality and new need for dialysis. SARS-CoV-2 pandemic prevented access to the buildings of the Centro Hospitalar Universitário Lisboa Norte, so the number of patients included did not reach the minimum calculated sample. It’s further planned to expand the sample to the estimated value, subsequently carrying out a statistical analysis of inference and building a predictive prognostic model using the WEKA tool for data mining. Nonetheless, the descriptive statistics is presented, as well as the concerning discussion.
Acute kidney injury (AKI) is considered one of the most serious complications in hospitalized patients, with an incidence in the hospitalized individuals estimated at 18.3%. This study aims to analyze the impact of several clinical and laboratory data in the prognosis regarding kidney function. This was a retrospective cohort study carried at Hospital de Santa Maria, with 152 patients. AKI was defined according to Kidney Disease; Improving Global Outcomes (KDIGO) criteria and Kidney Recovery according to 2019 Guideline of the UK Renal Association. The primary outcome was kidney recovery at the time of discharge and the secondary outcomes were kidney recover 2 to 4 months later, 28-day mortality and new need for dialysis. SARS-CoV-2 pandemic prevented access to the buildings of the Centro Hospitalar Universitário Lisboa Norte, so the number of patients included did not reach the minimum calculated sample. It’s further planned to expand the sample to the estimated value, subsequently carrying out a statistical analysis of inference and building a predictive prognostic model using the WEKA tool for data mining. Nonetheless, the descriptive statistics is presented, as well as the concerning discussion.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2020
Palavras-chave
Lesão renal aguda Prognóstico Recuperação renal