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Microcomposites theophylline/hydrogenated palm oil from a PGSS process for controlled drug delivery systems

2004Artigo científico Apenas metadados
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dc.contributor.authorRodrigues, M
dc.contributor.authorPeirico, N
dc.contributor.authorMatos, H
dc.contributor.authorde Azevedo, EG
dc.contributor.authorLobato, MR
dc.contributor.authorAlmeida, AJ
dc.date.accessioned2015-12-30T10:17:15Z
dc.date.available2015-12-30T10:17:15Z
dc.date.issued2004
dc.description.abstractNew controlled-release carriers of theophylline prepared with hydrogenated palm oil (HPO) were obtained by Particles from gas saturated solutions (PGSS) at different working pressures. Pressure had no significant effect on the mean diameter of the particles (of about 3.0 mum). However, spherical morphology with a regular surface was preferentially obtained at higher expansion pressures. HPLC analysis revealed a low theophylline encapsulation in the HPO matrix and showed that considerable amounts of theophylline were located at the particles' surface. Dissolution studies showed that theophylline released from the HPO matrix follows Higuchi's model for simple diffusional processes. However, successful correlation with experiment was achieved only with the Brophy and Deasy long-time correction to the Higuchi equation. (C) 2003 Elsevier B.V. All rights reserved.
dc.formatapplication/pdf
dc.identifier.citationJOURNAL OF SUPERCRITICAL FLUIDS. - Vol. 29, n. 40210 (APR 2004), p. 175-184
dc.identifier.doihttp://dx.doi.org/10.1016/S0896-8446(03)00034-2
dc.identifier.issn0896-8446
dc.identifier.urihttp://hdl.handle.net/10451/20983
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.subjectChemistry, Physical
dc.subjectEngineering, Chemical
dc.titleMicrocomposites theophylline/hydrogenated palm oil from a PGSS process for controlled drug delivery systems
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage184por
oaire.citation.startPage175por
oaire.citation.titleJOURNAL OF SUPERCRITICAL FLUIDSpor
oaire.citation.volumeVol. 29por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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