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Cataract surgery and IOP: a systematic review of randomised controlled trials

2022Journal article Restricted access
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dc.contributor.authorBrízido, Margarida
dc.contributor.authorRodrigues, Pedro Filipe
dc.contributor.authorAlmeida, Ana C.
dc.contributor.authorPinto, Luis
dc.date.accessioned2023-05-04T13:47:35Z
dc.date.available2023-05-04T13:47:35Z
dc.date.issued2022
dc.description© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022pt_PT
dc.description.abstractPurpose: Cataract and glaucoma are two of the most common ocular comorbidities. Cataract surgery has been shown to influence intra-ocular pressure (IOP) in patients with glaucoma; nevertheless, the extent of this effect remains controversial, especially in patients with open-angle glaucoma (OAG). The aim of this review is to determine the real effect of cataract surgery on IOP change in patients with OAG, focusing on data retrieved from randomised controlled trials (RCTs). Methods: A systematic review was performed, including six different RCTs that studied the net effect of cataract surgery on IOP. Eligibility criteria required a full washout from hypotensive therapy, allowing accurate measurement of unmedicated IOP, both before and after surgery. Results: Included studies revealed a consistent reduction on IOP occurring after surgery, varying between 4.1 and 8.5 mmHg depending on the RCT. There was also a decrease in the number of glaucoma medications, with a mean reduction of 0.2-1.0 agents postoperatively. Evaluation of adverse outcomes of cataract surgery showed a very favourable safety profile. Conclusion: Although the role of cataract surgery in the algorithm of glaucoma treatment remains to be established, this review highlights a consistent decrease on IOP following surgery and a reduced dependency on glaucoma medications. Potential downgrade in medication can thus be considered in well-controlled glaucoma patients after phacoemulsification.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraefes Arch Clin Exp Ophthalmol. 2023 May;261(5):1257-1266pt_PT
dc.identifier.doi10.1007/s00417-022-05911-3pt_PT
dc.identifier.eissn1435-702X
dc.identifier.issn0721-832X
dc.identifier.urihttp://hdl.handle.net/10451/57352
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/417pt_PT
dc.subjectCataractpt_PT
dc.subjectGlaucomapt_PT
dc.subjectIntra-ocular pressure reductionpt_PT
dc.subjectPhacoemulsificationpt_PT
dc.subjectSystematic reviewpt_PT
dc.titleCataract surgery and IOP: a systematic review of randomised controlled trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1266pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1257pt_PT
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
oaire.citation.volume261pt_PT
person.familyNameAbegão Pinto
person.givenNameLuis
person.identifier.ciencia-idF216-4AFA-8E65
person.identifier.orcid0000-0002-9960-7579
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationac0af1be-ba49-41eb-9e2f-8d22afb92af0
relation.isAuthorOfPublication.latestForDiscoveryac0af1be-ba49-41eb-9e2f-8d22afb92af0

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