A carregar...
Publicação
Plantas e produtos vegetais com ação no sistema hepatobiliar
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.29 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
A lesão ou disfunção hepática é considerada um problema grave de saúde. De acordo com a Organização Mundial da Saúde, as patologias de natureza hepática representam o quinto maior fator de mortalidade na União Europeia, podendo evoluir para quadros mais severos de fibrose hepática e cirrose.
Além disso, em termos de toxicidade, o fígado é frequentemente o órgão alvo. Muitos produtos xenobióticos podem causar toxicidade no fígado e subsequentemente induzir stress oxidativo, esteatose e morte celular. A maioria dos medicamentos, especialmente, antidepressivos, anti- câncer, anti-analgésico e anti-inflamatório podem ser hepatotóxicos. Os próprios medicamentos sintéticos para tratar doenças hepáticas, com o uso prolongado, podem causar efeitos adversos graves.
Por isso, as plantas medicinais com ação no sistema hepatobiliar têm o importante papel no tratamento e na prevenção destas doenças. Embora, só a correta utilização dessas plantas pode contribuir para a melhoria da saúde, visto que o uso inadequado pode acarretar efeitos negativos.
Nas últimas décadas, o interesse populacional pelas terapias naturais tem sido aumentado significativamente nos países industrializados, onde o resgate dos tratamentos naturais encara um avanço por novas pesquisas para a descoberta de novas alternativas no tratamento de diferentes tipos de doenças.
Assim, as plantas medicinais constituem uma importante fonte de inovação na saúde, sendo objeto de interesses empresariais privados, devido a tendência nos países desenvolvidos, os medicamentos à base de plantas deixam de se apoiar só no uso tradicional, mas sim, cada vez mais, em ensaios farmacológicos e clínicos.
O presente trabalho teve como objetivo descrever as plantas e produtos vegetais e os benefícios de sua utilização para portadores de patologias hepática. Entre as plantas com maior importância, com ação no sistema hepatobiliar, neste trabalho estão descritos: Artemisia absinthium L., Curcuma longa L., Cynara cardunculus L., Helichrysum arenarium (L.) Moench, Peumus boldus Molina e Silybum marianum (L.) Gaertn.
Através da pesquisa bibliográfica, neste trabalho pretendeu-se reunir um conjunto de estudos científicos que têm vindo a ser desenvolvidos sobre o tema acima referido.
Liver damage or dysfunction is considered a serious health problem. According to the World Health Organization, pathologies of a hepatic nature represent the fifth largest mortality factor in the European Union, as may progress to more severe liver fibrosis and cirrhosis. Additionally, in terms of toxicity, the liver is often the targeted organ. Many xenobiotic products can cause toxicity in the liver and subsequently induce oxidative stress, steatosis and cell death. Most medications, especially antidepressants, anti-cancer, anti-analgesics and anti-inflammatory drugs can be hepatotoxic. Synthetic drugs themselves to treat liver disease, with prolonged use, can cause serious adverse effects. That is why, medicinal plants acting on the hepatobiliary system play an important role in the treatment and prevention of these diseases. However, only the correct use of these plants can contribute to the improvement of health, since improper use can have negative effects. In the last decades, the population's interest in natural therapies has been significantly increased in industrialized countries, where the rescue of natural treatments faces an advance by new research to discover new alternatives in the treatment of different types of diseases. Thus, medicinal plants are an important source of innovation in health, being the object of private business interests, due to the trend in developed countries, herbal medicines no longer rely only on traditional use, but, increasingly, in pharmacological and clinical trials. This study aimed to describe plants and plant products and the benefits of their use for patients with liver disease. Among the most important plants with action on the hepatobiliary system, in this work are described: Artemisia absinthium L., Curcuma longa L., Cynara cardunculus L., Helichrysum arenarium (L.) Moench, Peumus boldus Molina and Silybum marianum (L.) Gaertn. Through bibliographic research, this work aimed to gather a set of scientific studies that have been developed on the above mentioned theme.
Liver damage or dysfunction is considered a serious health problem. According to the World Health Organization, pathologies of a hepatic nature represent the fifth largest mortality factor in the European Union, as may progress to more severe liver fibrosis and cirrhosis. Additionally, in terms of toxicity, the liver is often the targeted organ. Many xenobiotic products can cause toxicity in the liver and subsequently induce oxidative stress, steatosis and cell death. Most medications, especially antidepressants, anti-cancer, anti-analgesics and anti-inflammatory drugs can be hepatotoxic. Synthetic drugs themselves to treat liver disease, with prolonged use, can cause serious adverse effects. That is why, medicinal plants acting on the hepatobiliary system play an important role in the treatment and prevention of these diseases. However, only the correct use of these plants can contribute to the improvement of health, since improper use can have negative effects. In the last decades, the population's interest in natural therapies has been significantly increased in industrialized countries, where the rescue of natural treatments faces an advance by new research to discover new alternatives in the treatment of different types of diseases. Thus, medicinal plants are an important source of innovation in health, being the object of private business interests, due to the trend in developed countries, herbal medicines no longer rely only on traditional use, but, increasingly, in pharmacological and clinical trials. This study aimed to describe plants and plant products and the benefits of their use for patients with liver disease. Among the most important plants with action on the hepatobiliary system, in this work are described: Artemisia absinthium L., Curcuma longa L., Cynara cardunculus L., Helichrysum arenarium (L.) Moench, Peumus boldus Molina and Silybum marianum (L.) Gaertn. Through bibliographic research, this work aimed to gather a set of scientific studies that have been developed on the above mentioned theme.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2020, Universidade de Lisboa, Faculdade de Farmácia.
Palavras-chave
Plantas medicinais Medicamentos à base de plantas Doenças hepatobiliares Hepatites Efeitos hepatoprotetores Mestrado integrado - 2020