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Tratamentos antifúngicos da pele e unhas: onicomicoses e pitiríase versicolor. Estado de arte
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O objectivo desta monografia foi rever as opções terapêuticas antifúngicas e suas condicionantes, actualmente disponíveis os profissionais de saúde, nomeadamente os farmacêuticos e em Portugal. Dado que esta área é tão abrangente, quer nas variantes patológicas, quer na diversidade terapêutica, foi dado enfoque a duas das dermatomicoses com maior prevalência, as onicomicoses causadas por fungos dermatófitos, e a pitiríase versicolor.
O trabalho foi estruturado de forma a permitir um enquadramento sequencial de conteúdos, estando dividido em duas partes. Na primeira foi feita uma abordagem fisiológica da pele e unhas, que permitiu a compreensão das particularidades das diferentes infecções fúngicas e dos seus agentes causais. Na segunda parte é cumprido o objectivo do trabalho, em que são aprofundadas as opções terapêuticas disponíveis nestas duas dermatomicoses. São abordados os principais grupos de antifúngicos e dentro destes as moléculas activas nestas patologias, com enfase nos mecanismos de acção, nas posologias e duração de tratamentos, bem como nas interacções medicamentosos e contra-indicações. Por último são ainda abordadas outras opções terapêuticas, como um dispositivo médico.
Por fim, é concluído que as opções terapêuticas disponíveis são eficazes e seguras sendo realçada a importância da intervenção farmacêutica na implementação, acompanhamento e monitorização dos tratamentos antifúngicos.
The aim of this monograph was to review the antifungal therapeutics options and their limitations, currently available to health professionals, namely pharmacists in Portugal. As this area is so comprehensive, both in pathological variants, either in therapeutic diversity, focus was given to two of the most prevalent dermatomycosis, nail infections caused by dermatophytes, and pityriasis versicolor. The study was structured to allow a framework sequence of content being divided into two parts. In the first was made a physiological approach of the skin and nails, which allowed the understanding of the particularities of different fungal infections and their causative agents. In the second part is attained the purpose of the work, detailing the therapeutic options in these two dermatomycosis. It covers the major groups of antifungal and within these, the active molecules in these diseases, with emphasis on mechanisms of action, the dosages and duration of treatment, as well as drug interactions and contraindications. Finally are also discussed other treatment options, such as a medical device. Lastly is concluded that, available therapeutic options are safe and effective, and is enhanced the importance of pharmaceutical intervention in the implementation, supervision and monitorization of antifungal treatments.
The aim of this monograph was to review the antifungal therapeutics options and their limitations, currently available to health professionals, namely pharmacists in Portugal. As this area is so comprehensive, both in pathological variants, either in therapeutic diversity, focus was given to two of the most prevalent dermatomycosis, nail infections caused by dermatophytes, and pityriasis versicolor. The study was structured to allow a framework sequence of content being divided into two parts. In the first was made a physiological approach of the skin and nails, which allowed the understanding of the particularities of different fungal infections and their causative agents. In the second part is attained the purpose of the work, detailing the therapeutic options in these two dermatomycosis. It covers the major groups of antifungal and within these, the active molecules in these diseases, with emphasis on mechanisms of action, the dosages and duration of treatment, as well as drug interactions and contraindications. Finally are also discussed other treatment options, such as a medical device. Lastly is concluded that, available therapeutic options are safe and effective, and is enhanced the importance of pharmaceutical intervention in the implementation, supervision and monitorization of antifungal treatments.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2013
Palavras-chave
Antifúngicos Onicomicoses Pitiríase versicolor Dermatomicoses Mestrado Integrado - 2013