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Hemorheological parameters are related to subclinical atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis patients

2011Journal article Restricted access
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dc.contributor.authorSantos, Maria José
dc.contributor.authorPedro, Luís M
dc.contributor.authorCanhao, Helena
dc.contributor.authorFernandes e Fernandes, José
dc.contributor.authorSilva, José Canas da
dc.contributor.authorFonseca, João Eurico
dc.contributor.authorSaldanha, Carlota
dc.date.accessioned2012-06-18T15:30:40Z
dc.date.available2012-06-18T15:30:40Z
dc.date.issued2011
dc.description© 2011 Elsevier Ireland Ltdeng
dc.description.abstractObjectives: Rheological characteristics of blood are strongly linked to atherothrombosis in the general population, but its contribution to atherosclerosis in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is currently unclear. This work examines the relationship between blood rheology, traditional cardiovascular (CV) risk factors, inflammation and subclinical atherosclerosis in SLE and RA. Methods:Wholeblood viscosity (WBV), plasma viscosity (PV), erythrocyte deformability (ED), aggregation (EA) and erythrocyte NO production were measured in 197 patients (96 SLE and 101 RA) and compared to 97 controls, all females without previous CV events. Clinical information was obtained and fasting lipids and acute phase reactants were measured. The relationship between hemorheological parameters, CV risk factors and inflammation was assessed in patients and the impact of these variables on carotid intima-media thickness (cIMT) was evaluated in univariate followed by multivariate regression analyses. Results: WBV and ED are significantly lower in patients, while EA is elevated as compared with controls. Hemorheological disturbances correlate with CV risk factors and markers of inflammation and are more profound in patients with metabolic syndrome. Multivariable analysis showed that menopause (OR 34.72, 95%CI 4.44–271.77), obesity (OR 4.09, 95%CI 1.00–16.68) and WBV (OR 3.98; 95%CI 1.23–12.83) are positively associated whereas current corticosteroid dose (OR 0.87; 95%CI 0.78–0.98), and erythrocyte NO production (OR 0.16; 95%CI 0.05–0.52) are negatively associated with cIMT. Conclusion: Disturbed hemorheological parameters in SLE and RA women are related to the presence of CV risk factors and inflammation. WBV and erythrocyte NO are independently associated with the early stages of atherosclerosis.eng
dc.description.sponsorshipThis work was supported by a grant from Fundação para a Ciência e a Tecnologia, Portugal (PIC/IC/82920/2007)eng
dc.identifier.citationAtherosclerosis 219 (2011) 821–826eng
dc.identifier.issn0021-9150
dc.identifier.urihttp://hdl.handle.net/10451/6538
dc.identifier.uridoi:10.1016/j.atherosclerosis.2011.08.026
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectRheumatoid arthritiseng
dc.subjectSystemic lupus erythematosuseng
dc.subjectHemorheologyeng
dc.subjectAtherosclerosiseng
dc.subjectInflammationeng
dc.titleHemorheological parameters are related to subclinical atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis patientseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage826por
oaire.citation.startPage821por
oaire.citation.titleAtherosclerosiseng
person.familyNamePedro
person.familyNameCanhao
person.familyNameFonseca
person.familyNameSaldanha
person.givenNameLuís
person.givenNameHelena
person.givenNameJoão
person.givenNameCarlota
person.identifier53901
person.identifier.ciencia-id0B14-1812-24DC
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0003-4310-9324
person.identifier.orcid0000-0002-3239-2809
person.identifier.orcid0000-0003-1432-3671
person.identifier.orcid0000-0002-5058-2112
person.identifier.scopus-author-id7004454630
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id7101983519
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication.latestForDiscovery48f3be39-37f9-44de-9c7e-22e49a89efe5

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