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Challenges of BDNF-based therapies : from common to rare diseases

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dc.contributor.authorMiranda-Lourenço, Catarina
dc.contributor.authorRibeiro Rodrigues, Leonor
dc.contributor.authorFonseca-Gomes, João
dc.contributor.authorTanqueiro, Sara
dc.contributor.authorBelo, Rita F.
dc.contributor.authorFerreira, Catarina B.
dc.contributor.authorRei, Nádia
dc.contributor.authorFerreira-Manso, Mafalda
dc.contributor.authorde Almeida-Borlido, Carolina
dc.contributor.authorCosta-Coelho, Tiago
dc.contributor.authorFreitas, Céline
dc.contributor.authorZavalko, Svitlana
dc.contributor.authorMouro, Francisco
dc.contributor.authorSebastião, Ana M
dc.contributor.authorXapelli, Sara
dc.contributor.authorRodrigues, Tiago M.
dc.contributor.authorDiógenes, Maria José
dc.date.accessioned2021-04-08T10:57:06Z
dc.date.available2021-04-08T10:57:06Z
dc.date.issued2020
dc.description© 2020 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractNeurotrophins are a well-known family of neurotrophic factors that play an important role both in the central and peripheral nervous systems, where they modulate neuronal survival, development, function and plasticity. Brain-derived neurotrophic factor (BDNF) possesses diverse biological functions which are mediated by the activation of two main classes of receptors, the tropomyosin-related kinase (Trk) B and the p75 neurotrophin receptor (p75NTR). The therapeutic potential of BDNF has drawn attention since dysregulation of its signalling cascades has been suggested to underlie the pathogenesis of both common and rare diseases. Multiple strategies targeting this neurotrophin have been tested; most have found obstacles that ultimately hampered their effectiveness. This review focuses on the involvement of BDNF and its receptors in the pathophysiology of Alzheimer's disease (AD), Amyotrophic Lateral Sclerosis (ALS) and Rett Syndrome (RTT). We describe the known mechanisms leading to the impairment of BDNF/TrkB signalling in these disorders. Such mechanistic insight highlights how BDNF signalling compromise can take various shapes, nearly disease-specific. Therefore, BDNF-based therapeutic strategies must be specifically tailored and are more likely to succeed if a combination of resources is employed.pt_PT
dc.description.sponsorshipThe work was supported by Fundação Calouste Gulbenkian and FMUL (grant awarded to T.M.R., 20130002/PEC/BG); Santa Casa da Misericórdia de Lisboa (MB37-2017); Fundação para a Ciência e Tecnologia (FCT, AdoRett – LISBOA-01- 0145-FEDER-031929/2017); Uni-versidade de Lisboa (grant awarded to C.M.L., BD2015); the Association Française du Syndrome de Rett; Program “Educaç ̃ao pela Ciˆencia” Bolsas CHLN/FMUL – GAPIC (Project No. 20190017); Twinning action (Syn-aNet) from the EU H2020 Programme; H2020-WIDESPREAD-05-2017- Twinning (EpiEpinet) (grant agreement No. 952455); and FCT/Minis-t ́erio da Ciˆencia, Tecnologia e Ensino Superior (MCTES), through the Fundos do Orçamento de Estado (UID/BIM/50005/2019). This work was supported by Fundaç ̃ao para a Ciˆencia e a Tecnologia (FCT), Lisboa, Portugal [Fellowship numbers: C.M.L (SFRH/BD/118238/2016), L.R.R (PD/BD/150344/2019), J.F.G (PD/BD/114441/2016), S.R.T (PD/BD/ 128091/2016), R.F.B (PD/BD/114337/2016), C.B.F (PD/BD/128390/ 2017), N.R (PD/BD/113463/2015pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPharmacol Res. 2020 Dec;162:105281pt_PT
dc.identifier.doi10.1016/j.phrs.2020.105281pt_PT
dc.identifier.eissn1096-1186
dc.identifier.issn1043-6618
dc.identifier.urihttp://hdl.handle.net/10451/47282
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation20130002/PEC/BGpt_PT
dc.relationMB37-2017pt_PT
dc.relationLISBOA-01-0145-FEDER-031929/201pt_PT
dc.relationBD2015pt_PT
dc.relation20190017pt_PT
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relationInstituto de Medicina Molecular
dc.relationRegulation of adenosine levels as a new therapeutic strategy for Rett Syndrome
dc.relationA definir
dc.relationBDNF receptor cleavage:relevance for Alzheimer´s Disease pathophysiology
dc.relationModulation of BDNF effects by adenosine: a new strategy for schizophrenia treatment - Adenosinergic signaling as a new pharmacological target for schizophrenia treatment
dc.relationKyotorphin as new pharmacological therapeutic strategy for Alzheimers Disease
dc.relationThe role of septins on synaptic function and on amyloid precursor protein processing
dc.relationCharacterization of neuromodulatory dysfunction in Amyotrophic Lateral Sclerosis ALS.
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/pharmacological-researchpt_PT
dc.subjectBrain-derived neurotrophic factor (BDNF)pt_PT
dc.subjectAdenosinept_PT
dc.subjectTrkB receptorpt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectAmyotrophic lateral sclerosispt_PT
dc.subjectRett Syndromept_PT
dc.titleChallenges of BDNF-based therapies : from common to rare diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardTitleInstituto de Medicina Molecular
oaire.awardTitleRegulation of adenosine levels as a new therapeutic strategy for Rett Syndrome
oaire.awardTitleA definir
oaire.awardTitleBDNF receptor cleavage:relevance for Alzheimer´s Disease pathophysiology
oaire.awardTitleModulation of BDNF effects by adenosine: a new strategy for schizophrenia treatment - Adenosinergic signaling as a new pharmacological target for schizophrenia treatment
oaire.awardTitleKyotorphin as new pharmacological therapeutic strategy for Alzheimers Disease
oaire.awardTitleThe role of septins on synaptic function and on amyloid precursor protein processing
oaire.awardTitleCharacterization of neuromodulatory dysfunction in Amyotrophic Lateral Sclerosis ALS.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F50005%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F118238%2F2016/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F114441%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F128091%2F2016/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F113463%2F2015/PT
oaire.citation.titlePharmacological Researchpt_PT
oaire.citation.volume162pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
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person.familyNameMiranda Lourenço
person.familyNameRibeiro Rodrigues
person.familyNameFonseca-Gomes
person.familyNameTanqueiro
person.familyNameBelo
person.familyNameHenriques Rei
person.familyNameFerreira Manso
person.familyNameDe Almeida Borlido
person.familyNameCosta-Coelho
person.familyNameFreitas
person.familyNameMouro
person.familyNameSebastião
person.familyNameXapelli
person.familyNameRodrigues
person.familyNamede Oliveira Diógenes Nogueira
person.givenNameCatarina
person.givenNameLeonor
person.givenNameJoão
person.givenNameSara
person.givenNameRita
person.givenNameNádia Raquel
person.givenNameMafalda
person.givenNameCarolina
person.givenNameTiago
person.givenNameCéline
person.givenNameFrancisco
person.givenNameAna M
person.givenNameSara
person.givenNameTiago M.
person.givenNameMaria José
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