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Streptococcus agalactiae causing neonatal infections in Portugal 2005-2015: diversification and emergence of a CC17/PI-2b multidrug resistant sublineage

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dc.contributor.authorMartins, Elisabete R.
dc.contributor.authorPedroso-Roussado, Cristiano
dc.contributor.authorMelo Cristino, José
dc.contributor.authorRamirez, Mário
dc.date.accessioned2021-07-22T16:57:03Z
dc.date.available2021-07-22T16:57:03Z
dc.date.issued2017
dc.descriptionCopyright © 2017 Martins, Pedroso-Roussado, Melo-Cristino, Ramirez and The Portuguese Group for the Study of Streptococcal Infections. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractThe molecular characterization of 218 GBS isolates recovered from neonatal invasive infections in Portugal in 2005-2015 revealed the existence of a small number of genetically distinct lineages that were present over a significant time-span. Serotypes III and Ia were dominant in the population, together accounting for >80% of the isolates. Clonal complex 17 included 50% of all isolates, highlighting the importance of the hypervirulent genetic lineage represented by serotype III ST17/rib/PI-1+PI-2b. Serotype Ia was represented mainly by ST23, previously reported as dominant among invasive disease in non-pregnant adults in Portugal, but also by ST24, showing an increased frequency among late-onset disease. Overall erythromycin resistance was 16%, increasing during the study period (p < 0.001). Macrolide resistance was overrepresented among CC1 and CC19 isolates (p < 0.001 and p = 0.008, respectively). While representatives of the hypervirulent CC17 lineage were mostly susceptible to macrolides, we identified for the first time in Europe a recently emerging sublineage characterized by the loss of PI-1 (CC17/PI-2b), simultaneously resistant to macrolides, lincosamides, and tetracycline, also exhibiting high-level resistance to streptomycin and kanamycin. The stability and dominance of CC17 among neonatal invasive infections in the past decades indicates that it is extremely well adapted to its niche; however emerging resistance in this genetic background may have significant implications for the prevention and management of GBS disease.pt_PT
dc.description.sponsorshipEM was supported by a grant from Fundação para a Ciência e a Tecnologia (SFRH/BPD/80038/2011). This work was partially funded by a grant from the governments of Iceland, Lichtenstein and Norway (EEA-PT06).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Microbiol. 2017 Mar 28;8:499.pt_PT
dc.identifier.doi10.3389/fmicb.2017.00499pt_PT
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/10451/49068
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationSTREPTOCOCCUS AGALACTIAE COLONIZATION: GENETIC DIVERSITY AND ADHESION MECHANISMS UNDERLYING PATHOGENESIS
dc.relation.publisherversionhttps://www.frontiersin.org/journals/microbiologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCC17pt_PT
dc.subjectStreptococcus agalactiaept_PT
dc.subjectAntimicrobial resistancept_PT
dc.subjectInvasive diseasept_PT
dc.subjectNeonatespt_PT
dc.titleStreptococcus agalactiae causing neonatal infections in Portugal 2005-2015: diversification and emergence of a CC17/PI-2b multidrug resistant sublineagept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BPD/80038/2011
oaire.awardTitleSTREPTOCOCCUS AGALACTIAE COLONIZATION: GENETIC DIVERSITY AND ADHESION MECHANISMS UNDERLYING PATHOGENESIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F80038%2F2011/PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume8pt_PT
oaire.fundingStreamOE
person.familyNameMartins
person.familyNamePedroso-Roussado
person.familyNameMelo Cristino
person.familyNameRamos de Almeida Ramirez
person.givenNameElisabete
person.givenNameCristiano
person.givenNameJosé
person.givenNameMário Nuno
person.identifierB-4993-2008
person.identifier.ciencia-id0C1E-2896-F1AE
person.identifier.ciencia-id9E14-6DD1-1989
person.identifier.ciencia-id871E-6AD6-F37C
person.identifier.ciencia-id9C1C-F2A2-4226
person.identifier.orcid0000-0002-0703-9982
person.identifier.orcid0000-0001-9286-9296
person.identifier.orcid0000-0001-8643-1722
person.identifier.orcid0000-0002-4084-6233
person.identifier.ridA-2607-2009
person.identifier.ridE-8623-2017
person.identifier.ridH-3726-2013
person.identifier.scopus-author-id22835470900
person.identifier.scopus-author-id57193792748
person.identifier.scopus-author-id7004053640
person.identifier.scopus-author-id7201568476
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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