Logo do repositório
 
Publicação

Predictors of functional capacity in patients with pulmonary hypertension

2015Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorPlácido, Rui
dc.contributor.authorMartins, Susana
dc.contributor.authorMarques, João Silva
dc.contributor.authorKovell, Lara
dc.contributor.authorGonçalves, Susana
dc.contributor.authorAlmeida, Ana G.
dc.contributor.authorDiogo, António Nunes
dc.contributor.authorPinto, Fausto J.
dc.date.accessioned2018-07-18T14:53:50Z
dc.date.available2018-07-18T14:53:50Z
dc.date.issued2015
dc.description© 2015 Plácido R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractIntroduction: The 6-minute walk test (6 MWT) distance is frequently used in the prediction of pulmonary hypertension (PH) prognosis. However, potential surrogates of this measure have not been established. We aim to describe the clinical, echocardiographic, and laboratorial criteria determining the 6 MWT distance in patients with PH. Methods: In 22 consecutive PH patients, functional capacity was evaluated by the 6 MWT distance and compared with levels of neurohormonal activation biomarkers and echocardiographic parameters for right ventricular (RV) function. Results: A correlation between the 6 MWT distance and several clinical parameters was found: Borg’s pre-test classification (R=-0.46; p=0.038); WHO functional class (p=0.029). Patients with higher levels of aldosterone (R=-0.46; p=0.030), renin (R=-0.43; p=0.046) and mid-regional pro-adrenomedullin (MR-proADM, R=-0.53; p=0.009) had worse 6 MWT performance. The opposite was true for natremia levels (R=0.55; p=0.006). There was a positive correlation between the 6 MWT distance and RV global longitudinal peak systolic strain rate and early diastolic strain rate (R=0.49; p=0.038 and R=-0.55; p=0.018, respectively). On multivariate analysis, only natremia and early diastolic strain rate were predictors of the 6 MWT distance. Conclusion: The 6 MWT distance correlated with renin-angiotensin-aldosterone system activation and parameters for RV myocardial deformation. The new biomarker MR-proADM proved to be useful in the prediction of the functional capacity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Pulm Respir Med 5: 290pt_PT
dc.identifier.doi10.4172/2161-105X.1000290pt_PT
dc.identifier.issn2161-105X
dc.identifier.urihttp://hdl.handle.net/10451/34242
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOMICS Internationalpt_PT
dc.relation.publisherversionhttps://www.omicsonline.org/pulmonary-respiratory-medicine.phppt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPulmonary hypertensionpt_PT
dc.subject6-Minute walk testpt_PT
dc.subjectBiomarkerspt_PT
dc.subjectEchocardiographypt_PT
dc.subjectPrognosispt_PT
dc.titlePredictors of functional capacity in patients with pulmonary hypertensionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue05pt_PT
oaire.citation.titleJournal of Pulmonary and Respiratory Medicinept_PT
oaire.citation.volume05pt_PT
person.familyNameAlmeida
person.familyNamePinto
person.givenNameAna Gomes de
person.givenNameFausto J.
person.identifier1308889
person.identifier.ciencia-id3610-3184-3042
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0003-0360-4363
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id55628683100
person.identifier.scopus-author-id7102740158
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7a34cb7e-96d7-426c-ac32-346c0c0fa68c
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublication.latestForDiscovery5f44176f-69f5-482c-83cd-ab94425a6ec3

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Predictors.pdf
Tamanho:
756.81 KB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.2 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

FM-CCUL-Artigos em Revistas Internacionais