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How useful is contrast-enhanced ultrasound in rheumatoid arthritis? A systematic review with meta-analysis on the comparison between contrast-enhanced ultrasound and colour or power Doppler ultrasound

2025Journal article Restricted access
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dc.contributor.authorPolido Pereira, Joaquim
dc.contributor.authorAntónio, Manuel
dc.contributor.authorHenriques, Susana Oliveira
dc.contributor.authorSabido, João
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorVieira de Sousa, Elsa Cristina
dc.contributor.authorD’Agostino, Maria Antonietta
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2025-08-01T15:08:03Z
dc.date.available2025-08-01T15:08:03Z
dc.date.issued2025
dc.description© Italian Society of Medical Radiology 2025pt_PT
dc.description.abstractObjective The primary objective was to evaluate the additional benefits of contrast-enhanced ultrasound (CEUS) compared to unenhanced Doppler ultrasound (DUS) for the identification of active synovitis in rheumatoid arthritis (RA). Methods We searched PubMed/MEDLINE and EMBASE (February 2024) for all English-written published reports of human studies including the use of CEUS for the study of synovitis in RA. The risk of bias of included studies was evaluated using the QUADAS tool. DUS and CEUS semiquantitative scores were transformed in binomial, and these data were extracted for meta-analysis. Results that we were unable to quantitatively aggregate were summarised qualitatively. Results Twenty-three studies using CEUS to evaluate 1117 joints from 827 subjects were included, of which 898 joints were from 669 RA patients. We performed a meta-analysis of 9 studies in active RA patients showing that from 474 joints evaluated by either PDUS/CDUS and CEUS, the synovitis detection was 49.2% and 83.8%, respectively, corresponding to a relative detection ratio (RDR) of 1.49 (95% CI 1.23–1.81) favouring CEUS. Heterogeneity of the data was moderate. In healthy subjects, CEUS detected no vascularisation in 4 studies. Discussion CEUS detects more microvascularisation than PDUS in active RA with an RDR of 1.49.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRadiol med (2025)pt_PT
dc.identifier.doi10.1007/s11547-025-02055-2pt_PT
dc.identifier.eissn1826-6983
dc.identifier.issn0033-8362
dc.identifier.urihttp://hdl.handle.net/10400.5/102633
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/journal/11547pt_PT
dc.subjectRheumatoid arthritispt_PT
dc.subjectSynovitispt_PT
dc.subjectContrast-enhanced ultrasoundpt_PT
dc.subjectMicrobubblespt_PT
dc.subjectMusculoskeletal ultrasoundpt_PT
dc.subjectDopplerpt_PT
dc.titleHow useful is contrast-enhanced ultrasound in rheumatoid arthritis? A systematic review with meta-analysis on the comparison between contrast-enhanced ultrasound and colour or power Doppler ultrasoundpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleLa Radiologia Medicapt_PT
person.familyNamePolido Pereira
person.familyNameAntónio
person.familyNameOliveira Henriques
person.familyNameFernandes
person.familyNameVieira de Sousa
person.familyNameFonseca
person.givenNameJoaquim
person.givenNameManuel
person.givenNameSusana
person.givenNameRicardo
person.givenNameElsa Cristina
person.givenNameJoão
person.identifier676523
person.identifier309018
person.identifier.ciencia-id9812-232A-B282
person.identifier.ciencia-idB712-B9A2-C85F
person.identifier.ciencia-id1519-509A-8B89
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-7188-8516
person.identifier.orcid0000-0003-4936-0528
person.identifier.orcid0000-0002-0947-5083
person.identifier.orcid0000-0002-7253-6475
person.identifier.orcid0000-0002-7170-8802
person.identifier.orcid0000-0003-1432-3671
person.identifier.ridC-7501-2015
person.identifier.scopus-author-id57204519284
person.identifier.scopus-author-id24436565500
person.identifier.scopus-author-id7101983519
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication757607f2-5ab2-4d9e-a968-ce37a7b9113c
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