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The association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdom

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dc.contributor.authorCabrita, Inês Zimbarra
dc.contributor.authorMohammed, Abubakar
dc.contributor.authorLayton, Mark
dc.contributor.authorGhorashian, Sara
dc.contributor.authorGilmore, Annette
dc.contributor.authorCho, Gavin
dc.contributor.authorHoward, Jo
dc.contributor.authorAnie, Kofi A.
dc.contributor.authorDesforges, Lynda
dc.contributor.authorBassett, Paul
dc.contributor.authorGrapsa, Julia
dc.contributor.authorHoward, Luke
dc.contributor.authorMahalingam, Gaia
dc.contributor.authorDawson, David
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorNihoyannopoulos, Petros
dc.contributor.authorDavies, Sally C.
dc.contributor.authorGibbs, J. Simon R.
dc.date.accessioned2018-09-03T13:32:03Z
dc.date.available2018-09-03T13:32:03Z
dc.date.issued2013
dc.description© 2013 John Wiley & Sons Ltd.pt_PT
dc.description.abstractRaised tricuspid regurgitant velocity (TRV) occurs in approximately 30% of adults with sickle cell disease (SCD), and has been shown to be an independent risk factor for death. TRV was assessed in 164 SCD patients who were subsequently followed up for survival. Raised pulmonary pressures were defined as a TRV jet ≥2.5 m/s on echocardiography. Elevated TRV was present in 29.1% of patients and it was associated with increased age and left atrial diameter. There were 15 deaths (9.1%) over a median of 68.1 months follow up; seven patients had increased TRV, and eight patients had a TRV<2.5 m/s. Higher TRV values were associated with a greater than 4-fold increased risk of death (Hazard Ratio: 4.48, 99% confidence interval 1.01-19.8), although we found a lower overall mortality rate than has been reported in previous studies. TRV was not an independent risk factor for death. We have confirmed the association between raised TRV and mortality in a UK SCD population whose disease severity appears to be less than that reported in previous studies. Further prospective studies are needed to more clearly characterize which patient factors modify survival in SCD patients with raised TRV.pt_PT
dc.description.sponsorshipDuring this study, Inês Zimbarra Cabrita had a doctoral grant (SFRH/BD/47751/2008) from the Fundac ~ao para a Ciência e a Tecnologia (FCT), Portugal. This study was supported by the National Institute for Health Research (NIHR) under the Biomedical Research Centre Scheme. We are grateful to the patients and staff of the Haematology Departments at Central Middlesex Hospital and at Hammersmith Hospital for their assistance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBritish Journal of Haematology, 2013, 162, 400-408pt_PT
dc.identifier.doi10.1111/bjh.12391pt_PT
dc.identifier.issn0007-1048
dc.identifier.urihttp://hdl.handle.net/10451/34739
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley and Sonspt_PT
dc.relationTHE HEART IN SICKLE CELL DISEASE. ROLE OF NON INVASIVE CARDIAC IMAGING BY ADVANCED ECHOCARDIOGRAPHY AND CARDIAC MAGNETIC RESONANCE ASSESSMENT OF MYOCARDIAL FUNCTION
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/13652141pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectPulmonary hypertensionpt_PT
dc.subjectMortalitypt_PT
dc.subjectSurvivalpt_PT
dc.subjectTricuspid regurgitation velocitypt_PT
dc.titleThe association between tricuspid regurgitation velocity and 5-year survival in a North West London population of patients with sickle cell disease in the United Kingdompt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/47751/2008
oaire.awardTitleTHE HEART IN SICKLE CELL DISEASE. ROLE OF NON INVASIVE CARDIAC IMAGING BY ADVANCED ECHOCARDIOGRAPHY AND CARDIAC MAGNETIC RESONANCE ASSESSMENT OF MYOCARDIAL FUNCTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F47751%2F2008/PT
oaire.citation.endPage408pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage400pt_PT
oaire.citation.titleBritish Journal of Haematologypt_PT
oaire.citation.volume162pt_PT
person.familyNamePinto
person.givenNameFausto J.
person.identifier1308889
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.orcid0000-0002-8034-4529
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7102740158
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublication.latestForDiscovery5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isProjectOfPublication6d465ce9-d304-4152-b84b-07eb8ba8da6c
relation.isProjectOfPublication.latestForDiscovery6d465ce9-d304-4152-b84b-07eb8ba8da6c

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