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A Diabetes mellitus é uma doença crónica e progressiva que perturba o metabolismo dos hidratos de carbono, das gorduras e das proteínas, e resulta numa escassez ou falta de produção de insulina e/ou redução da sensibilidade dos tecidos à insulina. A Diabetes mellitus não causa apenas hiperglicemia, mas também uma série de complicações secundárias como hiperlipidemia, nefropatia diabética e insuficiência hepática. O alívio das complicações da diabetes é tão importante no tratamento desta patologia como reduzir os níveis de glicemia.
Esta dissertação tem como base uma revisão da literatura focando-se temporalmente nos últimos 5 anos. No total, são apresentadas 20 plantas que são tradicionalmente utilizadas para tratar a diabetes na medicina tradicional, os seus marcadores e alguns dos seus mecanismos de acção. Os resultados obtidos permitem verificar que os produtos alvo de estudos, possuem mecanismos de acção que permitem controlar os processos inflamatórios, não se limitando apenas a actuar na via de sinalização da insulina.
Pela sua multiplicidade de efeitos e de mecanismos de acção, as plantas constituem uma alternativa terapêutica válida para o tratamento da Diabetes mellitus tipo 2, desde que devidamente validada a utilidade do seu uso garantindo a sua qualidade e segurança.
Diabetes mellitus is a chronic, progressive disease that disrupts the metabolism of carbohydrates, fats and proteins, resulting in a shortage or lack of insulin production and/or reduced tissue sensitivity to insulin. Diabetes mellitus not only causes hyperglycemia, but also several secondary complications such as hyperlipidemia, diabetic nephropathy and liver failure. Relieving complications of diabetes is as important in treating this condition as reducing blood sugar levels. This dissertation is based on a review of the literature focusing on the last 5 years. In total, 20 plants that are traditionally used to treat diabetes in traditional medicine as well as its constituents and some of its mechanisms of action are presented. The obtained results allow to verify that the target products of studies, have mechanisms of action that don´t act only in the insulin pathway, but also control the inflammatory processes. Due to its multiplicity of effects and mechanisms of action, plants are a valid therapeutic alternative for the treatment of type 2 Diabetes mellitus, provided that the utility of its use is duly validated, guaranteeing its quality and safety.
Diabetes mellitus is a chronic, progressive disease that disrupts the metabolism of carbohydrates, fats and proteins, resulting in a shortage or lack of insulin production and/or reduced tissue sensitivity to insulin. Diabetes mellitus not only causes hyperglycemia, but also several secondary complications such as hyperlipidemia, diabetic nephropathy and liver failure. Relieving complications of diabetes is as important in treating this condition as reducing blood sugar levels. This dissertation is based on a review of the literature focusing on the last 5 years. In total, 20 plants that are traditionally used to treat diabetes in traditional medicine as well as its constituents and some of its mechanisms of action are presented. The obtained results allow to verify that the target products of studies, have mechanisms of action that don´t act only in the insulin pathway, but also control the inflammatory processes. Due to its multiplicity of effects and mechanisms of action, plants are a valid therapeutic alternative for the treatment of type 2 Diabetes mellitus, provided that the utility of its use is duly validated, guaranteeing its quality and safety.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2017
Palavras-chave
Diabetes mellitus Plantas Terapia Mestrado Integrado - 2017
