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Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia

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dc.contributor.authorFoxall, R. B.
dc.contributor.authorAlbuquerque, A. S.
dc.contributor.authorSoares, R. S.
dc.contributor.authorBaptista, A. P.
dc.contributor.authorCavaleiro, R.
dc.contributor.authorTendeiro, R.
dc.contributor.authorGomes, P.
dc.contributor.authorVictorino, R. M.
dc.contributor.authorSousa, A. E.
dc.date.accessioned2015-06-17T10:59:03Z
dc.date.available2015-06-17T10:59:03Z
dc.date.issued2011
dc.description© 2011 Wolters Kluwer Health | Lippincott Williams & Wilkinseng
dc.description.abstractObjective: The dynamics of CD4+ regulatory T cells (Treg) during HIV-1 infection remains unclear. To further investigate Treg in this context, we characterized, for the first time, this population in HIV-2-positive individuals. Although both HIV infections are associated with hyperimmune activation and CD4+ T-cell lymphopenia, most HIV-2-positive individuals display slower disease progression and low-to-undetectable viremia. Design/methods: Samples were obtained from cohorts of untreated HIV-2-positive and HIV-1-positive, treated HIV-1-positive and seronegative individuals. The proportion of CD4+ T cells bearing a Treg phenotype, defined in terms of high-level CD25 or Foxp3 expression, was assessed by flow cytometry and correlated with markers of disease progression. The proportions of naive and memory-like subsets as well as cycling cells were determined. Results: We observed an increased proportion of Treg, associated with disease progression, as well as increased proportions of cycling (Ki67+) memory Treg, in untreated HIV-2-positive and HIV-1-positive individuals. We also noted an expansion of Treg that persisted over time in treated, immunologically discordant HIV-1-positive individuals, who, similarly to HIV-2-positive patients, present undetectable viremia and low CD4 T-cell count. Conclusion: Overall, we demonstrated that Treg frequency was increased in all lymphopenic HIV-2-positive and HIV-1-positive individuals irrespective of the presence or absence of viremia or antiretroviral treatment. This, in turn, suggests that the observed alterations in Treg frequency in HIV/AIDS are more directly related to the degree of CD4 depletion than to viremia.eng
dc.description.sponsorshipThis work was supported by grants from ‘Fundação para a Ciência e a Tecnologia’ (FCT) and by ‘Programa Operacional Ciência e Inovaçao 2010’ (POCI2010), as well as from Fundação Calouste Gulbenkian to A.E.S. R.B.F., R.S.S., A.S.A., A.P.B., R.C. and R.T. received scholarships from FCT.eng
dc.identifier.citationAIDS 2011, 25:1961–1970por
dc.identifier.issn0269-9370
dc.identifier.urihttp://journals.lww.com/aidsonline/Fulltext/2011/10230/Memory_and_naive_like_regulatory_CD4__T_cells.4.aspx
dc.identifier.urihttp://dx.doi.org/10.1097/QAD.0b013e32834b3554
dc.identifier.urihttp://hdl.handle.net/10451/18295
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectHIV/AIDSeng
dc.subjectHIV-2eng
dc.subjectImmune activationeng
dc.subjectRegulatory T cellseng
dc.titleMemory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremiaeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleAIDS: Official Journal of the International Aids Societyeng
rcaap.rightsclosedAccesspor
rcaap.typearticlepor

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