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Occasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosis

2020Artigo científico Acesso restrito
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dc.contributor.authorSwash, Michael
dc.contributor.authorBurke, David
dc.contributor.authorTurner, Martin R.
dc.contributor.authorGrosskreutz, Julian
dc.contributor.authorLeigh, P. Nigel
dc.contributor.authorCarvalho, Mamede
dc.contributor.authorKiernan, Matthew C.
dc.date.accessioned2021-12-10T14:36:34Z
dc.date.available2021-12-10T14:36:34Z
dc.date.issued2020
dc.description© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.pt_PT
dc.description.abstractThe diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower motor neuron (LMN) and upper motor neuron (UMN) dysfunction. However, classical UMN signs are frequently difficult to identify in ALS. LMN involvement is sensitively detected by electromyography (EMG), but, as yet, there are no generally accepted markers for monitoring UMN abnormalities, the neurobiology of ALS itself and disease spread through the brain and the spinal cord.pt_PT
dc.description.sponsorshipMCK receives funding support from the National Health and Medical Research Council of Australia Program (grant number 1132524), Partnership Project (number 1153439) and Practitioner Fellowship (number1156093). PNL is supported by funding from the European Union H2020 Program (grant number 633413), the MND Association, the Dunhill Trust and the Wellcome Trust. JG is supported by the Dt. Gesellschaft für Muskelkranke.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJournal of neurology, neurosurgery, and psychiatry, 91(3), 227–234pt_PT
dc.identifier.doi10.1136/jnnp-2019-321938pt_PT
dc.identifier.eissn1468-330X
dc.identifier.issn0022-3050
dc.identifier.urihttp://hdl.handle.net/10451/50335
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Group Ltd.pt_PT
dc.relationEfficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients
dc.relation.publisherversionhttps://jnnp.bmj.com/pt_PT
dc.titleOccasional essay: Upper motor neuron syndrome in amyotrophic lateral sclerosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber633413
oaire.awardTitleEfficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/633413/EU
oaire.citation.endPage234pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage227pt_PT
oaire.citation.titleJournal of Neurology, Neurosurgery & Psychiatrypt_PT
oaire.citation.volume91pt_PT
oaire.fundingStreamH2020
person.familyNameSwash
person.familyNamede Carvalho
person.givenNameMichael
person.givenNameMamede
person.identifier.orcid0000-0002-8717-8914
person.identifier.orcid0000-0001-7556-0158
person.identifier.scopus-author-id7101990692
person.identifier.scopus-author-id7101893769
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc6014014-de11-4f31-ac1a-096c54052517
relation.isAuthorOfPublicationdd7f55d4-c2b5-4fd2-9bd1-a9542a62f58f
relation.isAuthorOfPublication.latestForDiscoveryc6014014-de11-4f31-ac1a-096c54052517
relation.isProjectOfPublicationdd94d17a-2f39-4b98-91f0-a77fec7d914d
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