Logo do repositório
 
Publicação

The impact of SSRIs on mortality and cardiovascular events in patients with coronary artery disease and depression : systematic review and meta-analysis

2020Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorFernandes, Nuno
dc.contributor.authorPrada, Luísa
dc.contributor.authorRosa, Mário Miguel
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorCosta, João
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorCaldeira, Daniel
dc.date.accessioned2020-07-21T10:42:32Z
dc.date.available2020-07-21T10:42:32Z
dc.date.issued2020
dc.description© Springer-Verlag GmbH Germany, part of Springer Nature 2020pt_PT
dc.description.abstractBackground: Depression is common in patients after acute coronary syndromes (ACS) and with stable coronary artery disease (CAD) and has been associated with increased mortality and morbidity. However, it is unclear whether selective serotonin receptor inhibitors (SSRIs) reduce mortality or cardiac events in patients with CAD and depression. Objective: We conducted a systematic review and meta-analysis to assess the efects of SSRIs on cardiovascular events in depressed CAD patients. Methods: The CENTRAL, MEDLINE, and PsycINFO databases were searched (April 2020) for randomized controlled trials (RCTs) and extended follow-up analyses of RCTs that compared SSRIs with placebo or no intervention in patients with CAD and depression. The primary outcomes were all-cause mortality, cardiovascular mortality, and myocardial infarction incidence. The results were calculated through random-efect meta-analyses and reported in terms of risk ratio (RR) with 95% confdence intervals (CI). Results: We retrieved 8 RCTs (2 of which with extended follow-up analyses), comprising a total of 1148 patients. 7 studies only included post-ACS patients. SSRIs were associated with a signifcantly lower risk of myocardial infarction in patients with CAD and depression (RR 0.54, 95% CI 0.34–0.86), and in post-ACS patients with depression (RR 0.56, 95% CI 0.35–0.90). We found no statistically signifcant diference in all-cause mortality, cardiovascular mortality, hospitalizations, angina, congestive heart failure, or stroke incidence. Conclusion: The use of SSRIs in post-ACS patients with depression was associated with a 44% relative risk reduction of myocardial infarction. No diference in mortality was found. Given that the quality of the evidence was low, further research is warranted.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Res Cardiol (2020).pt_PT
dc.identifier.doi10.1007/s00392-020-01697-8pt_PT
dc.identifier.eissn1861-0692
dc.identifier.issn1861-0684
dc.identifier.urihttp://hdl.handle.net/10451/44072
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/392/pt_PT
dc.subjectAcute coronary syndromept_PT
dc.subjectMyocardial infarctionpt_PT
dc.subjectUnstable anginapt_PT
dc.subjectCoronary artery diseasept_PT
dc.subjectDepressionpt_PT
dc.subjectAnxietypt_PT
dc.subjectSelective serotonin receptor inhibitorpt_PT
dc.subjectSSRIpt_PT
dc.subjectSecondary preventionpt_PT
dc.subjectSystematic reviewpt_PT
dc.titleThe impact of SSRIs on mortality and cardiovascular events in patients with coronary artery disease and depression : systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleClinical Research in Cardiologypt_PT
person.familyNameFernandes
person.familyNamePrada
person.familyNameCOELHO DA SILVA ROSA
person.familyNameFerreira
person.familyNameCosta
person.familyNamePinto
person.familyNameCaldeira
person.givenNameNuno
person.givenNameLuísa
person.givenNameMÁRIO MIGUEL
person.givenNameJoaquim J
person.givenNameJoão
person.givenNameFausto J.
person.givenNameDaniel
person.identifier1624753
person.identifier480560
person.identifier1308889
person.identifier.ciencia-id2610-0EC0-FE33
person.identifier.ciencia-idAD12-9209-3302
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.ciencia-idAA19-EC35-8D01
person.identifier.orcid0000-0002-9566-6838
person.identifier.orcid0000-0002-7082-7594
person.identifier.orcid0000-0003-3158-2106
person.identifier.orcid0000-0003-3950-5113
person.identifier.orcid0000-0002-5831-4921
person.identifier.orcid0000-0002-8034-4529
person.identifier.orcid0000-0002-2520-5673
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7403252466
person.identifier.scopus-author-id55499748300
person.identifier.scopus-author-id7102740158
person.identifier.scopus-author-id36623384200
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication36e52289-d4b8-4ea8-b220-0a69a4d427cb
relation.isAuthorOfPublicationd2fb22d2-cf54-443f-974a-917b57c45856
relation.isAuthorOfPublication7a1bfd39-f7e2-461d-9409-72b34b799ad7
relation.isAuthorOfPublication54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isAuthorOfPublication0924f405-2d3a-4914-9097-24aa639bd97f
relation.isAuthorOfPublication5f44176f-69f5-482c-83cd-ab94425a6ec3
relation.isAuthorOfPublicationeba36bb8-5eb3-4ccc-88f8-bd7012d42382
relation.isAuthorOfPublication.latestForDiscoveryeba36bb8-5eb3-4ccc-88f8-bd7012d42382

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Impact_SSRIs.pdf
Tamanho:
906.09 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

FM-CCUL-Artigos em Revistas Internacionais
FM-CEMBE-Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais