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Real-world effectiveness in hypertension and hyperlipidemia collaborative management between pharmacies and primary care in Portugal: a multicenter pragmatic controlled trial (USFarmácia®)

2023Journal article Open access
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dc.contributor.authorCosta, Suzete
dc.contributor.authorBiscaia, José Luís
dc.contributor.authorHorta, Maria Rute
dc.contributor.authorRomano, Sónia
dc.contributor.authorGuerreiro, José
dc.contributor.authorHeudtlass, Peter
dc.contributor.authorCary, Maria
dc.contributor.authorRomão, Mariana
dc.contributor.authorTeixeira Rodrigues, António
dc.contributor.authorMiranda, Ana
dc.contributor.authorMartins, Ana Paula
dc.contributor.authorBento, Ana Sofia
dc.contributor.authorPereira, João
dc.contributor.authorMateus, Céu
dc.contributor.authorHelling, Dennis K.
dc.date.accessioned2023-09-19T13:27:16Z
dc.date.available2023-09-19T13:27:16Z
dc.date.issued2023
dc.descriptionCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_PT
dc.description.abstractThere is evidence of the efficacy of collaborative health interventions with pharmacies and primary care providers but little of its real-world effectiveness. We aimed to assess the effectiveness and discuss the design and challenges of hypertension and hyperlipidemia management between pharmacies and primary care providers using real-world data exchange between providers and experimental bundled payment. This was a pragmatic, quasi-experimental controlled trial. We collected patient-level data from primary care prescription claims and Electronic Medical Record databases, a pharmacy claims database, and patient telephone surveys at several time points. The primary outcomes were changes in blood pressure and total cholesterol. We used matched controls with difference-in-differences estimators in a Generalized Linear Model (GLM) and controlled interrupted time series (CITS). We collected additional data for economic and qualitative studies. A total of 6 Primary Care Units, 20 pharmacies, and 203 patients entered the study. We were not able to observe significant differences in the effect of intervention vs. control. We experienced challenges that required creative strategies. This real-world trial was not able to show effectiveness, likely due to limitations in the primary care technology which affected the sample size. It offers, however, valuable lessons on methods, strategies, and data sources, paving the way for more real-world effectiveness trials to advance value-based healthcare.pt_PT
dc.description.sponsorshipThis trial was promoted by the Agrupamento dos Centros de Saúde (ACeS) (NHS Group of Primary Care Units) of the Baixo Mondego Region and the Associação Nacional das Farmácias (ANF) (Portuguese National Association of Pharmacies) and was funded by the ANF. Hartmann supplied blood pressure monitors to intervention pharmacies. Trial Registration Number: ISRCTN13410498. S.C. paid for the open-access publication fee for this manuscript.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Environ Res Public Health. 2023 Aug 1;20(15):6496pt_PT
dc.identifier.doi10.3390/ijerph20156496pt_PT
dc.identifier.eissn1660-4601
dc.identifier.issn1661-7827
dc.identifier.urihttp://hdl.handle.net/10451/59371
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/ijerphpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCollaborativept_PT
dc.subjectCommunity pharmacypt_PT
dc.subjectEffectivenesspt_PT
dc.subjectHyperlipidemiapt_PT
dc.subjectHypertensionpt_PT
dc.subjectPharmacy servicespt_PT
dc.subjectPrimary carept_PT
dc.subjectPublic health interventionspt_PT
dc.subjectReal-worldpt_PT
dc.subjectTrialpt_PT
dc.titleReal-world effectiveness in hypertension and hyperlipidemia collaborative management between pharmacies and primary care in Portugal: a multicenter pragmatic controlled trial (USFarmácia®)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue15pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume20pt_PT
person.familyNameCosta
person.familyNameMartins
person.givenNameSuzete
person.givenNameAna Paula
person.identifier.orcid0000-0002-4521-5473
person.identifier.orcid0000-0002-5064-6171
person.identifier.scopus-author-id56358454500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication44ded07d-217a-4c1d-bd60-934fa4097aac
relation.isAuthorOfPublication49a187c1-adec-4644-8e07-72c1f3243346
relation.isAuthorOfPublication.latestForDiscovery44ded07d-217a-4c1d-bd60-934fa4097aac

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