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Combination of trans-resveratrol and E-viniferin induces a hepatoprotective effect in rats with severe acute liver failure via reduction of oxidative stress and MMP-9 expression

2021Journal article Open access
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dc.contributor.authorFernandes, João C.
dc.contributor.authorSchemitt, Elizangela
dc.contributor.authorSilva, Juliana
dc.contributor.authorMarroni, Norma P.
dc.contributor.authorLima, Ana
dc.contributor.authorFerreira, Ricardo Boavida
dc.date.accessioned2021-11-04T12:23:31Z
dc.date.available2021-11-04T12:23:31Z
dc.date.issued2021
dc.description.abstractStilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + "-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-"-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + "- viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNF , iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + "-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNF , COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional dietspt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes, J.C.; Schemitt, E.G.; Da Silva, J.; Marroni, N.P.; Lima, A.; Ferreira, R.B. Combination of Trans-Resveratrol and E-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression. Nutrients 2021, 13, 3677pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/22494
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/AGR/04129/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectinflammationpt_PT
dc.subjectliver failurept_PT
dc.subjectMMP-9pt_PT
dc.subjectoxidative stresspt_PT
dc.subjectresveratrolpt_PT
dc.subjectstilbenespt_PT
dc.subjectthioacetamidept_PT
dc.subjectE-viniferinpt_PT
dc.titleCombination of trans-resveratrol and E-viniferin induces a hepatoprotective effect in rats with severe acute liver failure via reduction of oxidative stress and MMP-9 expressionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/62527/PT
oaire.citation.titleNutrientspt_PT
oaire.fundingStreamOE
person.familyNameFerreira
person.givenNameRicardo Boavida
person.identifier86030
person.identifier.ciencia-id371D-28A0-4027
person.identifier.orcid0000-0002-5027-7564
person.identifier.scopus-author-id8285312700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0f32c437-6c87-47d7-998b-c97c4695806a
relation.isAuthorOfPublication.latestForDiscovery0f32c437-6c87-47d7-998b-c97c4695806a
relation.isProjectOfPublicationc5fe9b9c-6186-41f4-abc4-79f6ec37f2fe
relation.isProjectOfPublication.latestForDiscoveryc5fe9b9c-6186-41f4-abc4-79f6ec37f2fe

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