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Combination of trans-resveratrol and E-viniferin induces a hepatoprotective effect in rats with severe acute liver failure via reduction of oxidative stress and MMP-9 expression
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Orientador(es)
Resumo(s)
Stilbenes are a major grapevine class of phenolic compounds, known for their biological
activities, including anti-inflammatory and antioxidant, but never studied in combination. We
aimed to evaluate the effect of trans-resveratrol + "-viniferin as an antioxidant mixture and its role
in inflammatory development an in vivo model of severe acute liver failure induced with TAA.
Trans-resveratrol + trans-"-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + "-
viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in
the treated group. This stilbene combination reduced the expression of TNF , iNOS, and COX-2,
and inhibited MMP-9. The combination of resveratrol + "-viniferin had a hepatoprotective effect,
reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD,
CAT, and GST activities; by downregulating TNF , COX-2, and iNOS; and upregulating IL-10. Our
results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than
resveratrol alone, opening a new perspective on using this stilbene combination in functional diets
Descrição
Palavras-chave
inflammation liver failure MMP-9 oxidative stress resveratrol stilbenes thioacetamide E-viniferin
Contexto Educativo
Citação
Fernandes, J.C.; Schemitt, E.G.; Da Silva, J.; Marroni, N.P.; Lima, A.; Ferreira, R.B. Combination of Trans-Resveratrol and E-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression. Nutrients 2021, 13, 3677