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Publicação
Combined central and peripheral demyelination after COVID-19 vaccination
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Orientador(es)
Resumo(s)
Combined central and peripheral demyelination (CCPD) is a rare neurological entity that afects both the central and peripheral nervous system with demyelinating lesions. The pattern of involvement of the central nervous system (CNS) includes frequent bilateral optical neuritis, involvement of grey matter and occasional longitudinally extensive transverse myelitis (LETM) in the absence of oligoclonal bands (OCB) or antibodies such as antiaquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG). Peripheral nervous system (PNS) involvement occurs mainly as a chronic infammatory demyelinating polyneuropathy
(CIDP)-like disease. Infections and vaccinations are known triggers. CCPD typically evolves aggressively
with progressive cumulative neurological impairment despite immunosuppression.
Descrição
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022.
Palavras-chave
Contexto Educativo
Citação
J Neurol. 2022 May 18;1-5
Editora
Springer Nature