Logo do repositório
 
Publicação

FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2

2015Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorFleskens, V.
dc.contributor.authorMokry, D. M.
dc.contributor.authorvan der Leun, A. M.
dc.contributor.authorHuppelschoten, S.
dc.contributor.authorPals, C. E. G. M.
dc.contributor.authorPeeters, J.
dc.contributor.authorCoenen, S.
dc.contributor.authorCardoso, Bruno A.
dc.contributor.authorBarata, João T.
dc.contributor.authorvan Loosdregt, J.
dc.contributor.authorCoffer, P. J.
dc.date.accessioned2022-06-14T11:39:38Z
dc.date.available2022-06-14T11:39:38Z
dc.date.issued2015
dc.description© 2015 Macmillan Publishers Limited. All rights reserved.pt_PT
dc.description.abstractT-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is associated with a differentiation block and self-renewal. The transcription factor Forkhead Box P3 (FOXP3) was recently described to be expressed in a variety of malignancies including T-ALL. Here we show that increased FOXP3 levels negatively correlate with expression of genes regulated by the oncogenic TAL1-complex in human T-ALL patient samples as well as a T-ALL cell line ectopically expressing FOXP3. In these cells, FOXP3 expression results in altered regulation of cell cycle progression and reduced cell viability. Finally, we demonstrate that FOXP3 binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1, providing a molecular mechanism for FOXP3-mediated transcriptional modulation in T-ALL. Collectively, our findings provide initial evidence for a novel role of FOXP3 as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity.pt_PT
dc.description.sponsorshipVF and JvL were supported by a grant from the Dutch Arthritis Foundation (Rheumafonds), and BAC was supported by a fellowship from Fundação para a Ciência e a Tecnologia. This work was supported by grant from the Dutch Arthritis Foundation (Rheumafonds), and a fellowship from Fundação para a Ciência e a Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOncogene. 2016 Aug 4;35(31):4141-4148pt_PT
dc.identifier.doi10.1038/onc.2015.481pt_PT
dc.identifier.eissn1476-5594
dc.identifier.issn0950-9232
dc.identifier.urihttp://hdl.handle.net/10451/53376
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/onc/pt_PT
dc.titleFOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4148pt_PT
oaire.citation.issue31pt_PT
oaire.citation.startPage4141pt_PT
oaire.citation.titleOncogenept_PT
oaire.citation.volume35pt_PT
person.familyNameCaetano Cardoso
person.familyNameBarata
person.givenNameBruno António
person.givenNameJoão
person.identifier.ciencia-id0F1A-378B-1157
person.identifier.orcid0000-0002-6521-7257
person.identifier.orcid0000-0002-4826-8976
person.identifier.ridD-9181-2015
person.identifier.scopus-author-id24402845200
person.identifier.scopus-author-id7006937224
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5d24249e-4cd5-4ba4-a935-7b8ec493330a
relation.isAuthorOfPublication06f27f7f-1c6c-4c03-a70d-52f8a388bd3b
relation.isAuthorOfPublication.latestForDiscovery5d24249e-4cd5-4ba4-a935-7b8ec493330a

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
FOXP3_modulate.pdf
Tamanho:
2.06 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais