Publicação
Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster
| datacite.subject.fos | Departamento de Biologia Vegetal | pt_PT |
| dc.contributor.advisor | Mendes, César S. | |
| dc.contributor.advisor | Carvalho, Margarida Henriques da Gama, 1972- | |
| dc.contributor.author | Andrade, Vasco Maria Horta e Costa Freire de | |
| dc.date.accessioned | 2024-01-25T09:55:44Z | |
| dc.date.available | 2024-01-25T09:55:44Z | |
| dc.date.issued | 2023 | |
| dc.date.submitted | 2023 | |
| dc.description | Tese de mestrado, Biologia Molecular e Genética, 2023, Universidade de Lisboa, Faculdade de Ciências | pt_PT |
| dc.description.abstract | Coordinated walking is a fundamental biological activity across the animal kingdom. When functioning correctly, it enables animals to forage for food, evade threats, and seek potential mates for reproduction. In the case of humans, our ability to walk in a coordinated manner significantly contributes to our overall quality of life. Therefore, gaining insights into the mechanisms underlying this activity and maintaining its health are of paramount importance. The fruit fly, Drosophila melanogaster, stands out as an excellent model for exploring this topic, thanks to its robust genetic tools and comprehensive kinematic measurement methods. Locomotion in fruit flies is regulated by basic circuits located in the ventral nerve cord, which are modulated by input from higher-level control centers in the central brain. These control centers process sensory information and adjust the walking patterns accordingly. One specific brain region, known as the central complex, serves as a higher-order motor control center. Comparable to the basal ganglia or cerebellum in vertebrates, the central complex comprises four subunits: ellipsoid body, fan-shaped body, noduli, and protocerebral bridge. Research has shown that these neural structures play a role in controlling various aspects of walking and goal-directed locomotion, among other functions. However, our understanding of the cellular and circuit-level mechanisms, as well as the detailed functions of these components, remains incomplete. This study has two main objectives: (1) to comprehend how central complex substructures impact diverse locomotion parameters and (2) to introduce an innovative approach for investigating the first objective further. The findings reveal the ability to link distinct central complex regions with various locomotion parameters, each showing varying degrees of influence. While the implemented approach is not yet fully developed, it shows potential for future research into the influence of central complex substructures on locomotion. | pt_PT |
| dc.identifier.tid | 203523997 | |
| dc.identifier.uri | http://hdl.handle.net/10451/62219 | |
| dc.language.iso | eng | pt_PT |
| dc.subject | comportamento | pt_PT |
| dc.subject | locomoção | pt_PT |
| dc.subject | central complex | pt_PT |
| dc.subject | Teses de mestrado - 2023 | pt_PT |
| dc.title | Understanding the influence of the central brain on coordinated walking using Drosophila melanogaster | pt_PT |
| dc.type | master thesis | |
| dspace.entity.type | Publication | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | masterThesis | pt_PT |
| thesis.degree.name | Tese de mestrado em Biologia Molecular e Genética | pt_PT |