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Smoking status and vascular risk factors as predictors of disability in AQP4-NMOSD and MOGAD

2025Journal article Open access
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dc.contributor.authorChan, Fiona
dc.contributor.authorBerhanu, David
dc.contributor.authorSamadzadeh, Sara
dc.contributor.authorFrancis, Anna
dc.contributor.authorAsgari, Nasrin
dc.contributor.authorPaul, Friedemann
dc.contributor.authorLeite, M Isabel
dc.contributor.authorGeraldes, Ruth
dc.contributor.authorPalace, Jacqueline
dc.date.accessioned2025-08-01T10:53:35Z
dc.date.available2025-08-01T10:53:35Z
dc.date.issued2025
dc.description© The Author(s), 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).pt_PT
dc.description.abstractBackground: Smoking and vascular risk factors (VRFs) are reported to have adverse effects in multiple sclerosis but data are limited in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD). This study aimed to measure their impact on disability. Methods: Smoking status was defined as never, past or current smokers and VRF comprised of ⩾1: hypertension, dyslipidemia, high body mass index or diabetes. Logistic regression models were fitted to predict their influence on recovery from onset attack and first optic neuritis (ON) attack. Results: A total of 442 patients were included. Current MOGAD smokers had a higher risk of disability from onset attack and first ON attack than never smokers (odds ratio (OR) 2.9, 95% confidence interval (CI) 1.3-6.9; OR 3.3, 95% CI 1.4-7.8). VRF in MOGAD was not predictive of disability. Current AQP4-NMOSD smokers and VRFs had a higher risk of residual disability from onset attacks (OR 7.5, 95% CI 2.1-27.7; OR 1.9, 95% CI 1.0-3.4). VRF was associated with higher risk of visual disability (OR 2.6, 95% CI 1.08-6.46) while smoking status was not. Conclusions: Current smoking status detrimentally influenced onset attack recovery in AQP4-NMOSD and MOGAD patients, including visual recovery in MOGAD. Non-smoking VRFs influenced clinical and visual outcomes in AQP4-NMOSD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMult Scler. 2025 May;31(6):658-667pt_PT
dc.identifier.doi10.1177/13524585251325069pt_PT
dc.identifier.eissn1477-0970
dc.identifier.issn1352-4585
dc.identifier.urihttp://hdl.handle.net/10400.5/102616
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSagept_PT
dc.relation.publisherversionhttps://journals.sagepub.com/home/MSJpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSmokingpt_PT
dc.subjectAquaporin-4 antibody-positive neuromyelitis optica spectrum disorderpt_PT
dc.subjectComorbiditiespt_PT
dc.subjectDisabilitypt_PT
dc.subjectMyelin oligodendrocyte glycoprotein antibody diseasept_PT
dc.subjectVascular risk factorspt_PT
dc.titleSmoking status and vascular risk factors as predictors of disability in AQP4-NMOSD and MOGADpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage667pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage658pt_PT
oaire.citation.titleMultiple Sclerosis Journalpt_PT
oaire.citation.volume31pt_PT
person.familyNameAlves Berhanu
person.givenNameDavid
person.identifier.ciencia-idB912-8429-153C
person.identifier.orcid0000-0003-1851-7182
person.identifier.scopus-author-id57192198642
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication297f2467-09c4-407c-ba80-91ec9db67cdb
relation.isAuthorOfPublication.latestForDiscovery297f2467-09c4-407c-ba80-91ec9db67cdb

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