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Estudo das lesões corneanas provocadas por laser de dióxido de carbono em animais de companhia
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Orientador(es)
Resumo(s)
O presente estudo teve como objectivos explorar o comportamento da córnea
quando lhe é incidida radiação laser de dióxido de carbono, verificar as características das
lesões obtidas, as alterações observadas quando se varia potência, tempo de incidência da
radiação laser e distância desta à córnea, e o uso potencial desta técnica no tratamento de
queratopatias com expressão clínica em oftalmologia veterinária.
Foram promovidas 245 lesões na córnea de olhos não enucleados de animais mortos.
Observou-se que este tipo de radiação laser promoveu a eliminação de uma ou mais
camadas da córnea. As lesões resultantes constituíram úlceras mais ou menos profundas. A
radiação laser produziu diversos tipos de lesões, sendo a queimadura da córnea uma delas.
Deste modo, devido à natureza delicada da córnea e a uma margem de erro muito pequena,
a selecção das variáveis utilizadas é critica.
Este estudo não pôde prever como a lesão da córnea se comportará in vivo e qual a sua
evolução cicatricial. No entanto, obtiveram-se algumas lesões com interesse de poderem ser
aplicadas. Sendo um estudo preliminar, investigações adicionais que avaliem os efeitos
agudos e crónicos são necessários antes que a técnica possa ser recomendada.
ABSTRACT - The objectives of the study were to determine the response of the corneal tissue upon the incidence of carbon dioxide laser radiation, analyse the obtained lesions and the change in their characteristics when parameters like radiation power, duration of incidence and distance between source of radiation and cornea were modified, and to assess the technique’s potential value in the treatment of keratopathies with clinical relevance in veterinary medicine, such as pigmentary keratitis. 245 lesions were induced in corneas of non-enucleated eyes of dead bodies of animals. The incidence of laser radiation eliminated several corneal layers, creating corneal ulcers with more or less depth. Different types of lesion were obtained, some of them apparently pose a greater deal of problem in terms of their potential to heal (corneal burns). Therefore, to avoid these lesions, the selection of operating parameters is critical. It’s not the purpose of this study to predict the behaviour of these laser-induced lesions in vivo. Some of the obtained ulcers seem manageable in terms of their cicatrisation and medical applications. This preliminary study should be a point of departure for further investigations to estimate the acute and chronic effects of this technique, prior to its application in clinical practice.
ABSTRACT - The objectives of the study were to determine the response of the corneal tissue upon the incidence of carbon dioxide laser radiation, analyse the obtained lesions and the change in their characteristics when parameters like radiation power, duration of incidence and distance between source of radiation and cornea were modified, and to assess the technique’s potential value in the treatment of keratopathies with clinical relevance in veterinary medicine, such as pigmentary keratitis. 245 lesions were induced in corneas of non-enucleated eyes of dead bodies of animals. The incidence of laser radiation eliminated several corneal layers, creating corneal ulcers with more or less depth. Different types of lesion were obtained, some of them apparently pose a greater deal of problem in terms of their potential to heal (corneal burns). Therefore, to avoid these lesions, the selection of operating parameters is critical. It’s not the purpose of this study to predict the behaviour of these laser-induced lesions in vivo. Some of the obtained ulcers seem manageable in terms of their cicatrisation and medical applications. This preliminary study should be a point of departure for further investigations to estimate the acute and chronic effects of this technique, prior to its application in clinical practice.
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
Laser de dióxido de carbono Córnea Queratite pigmentar Carbon dioxide laser Pigmentary keratitis
Contexto Educativo
Citação
Editora
Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária