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Post-exercise differential response of central and brachial blood pressure in patients with coronary artery disease: a randomized crossover trial

2025Journal article Open access
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dc.contributor.authorMarôco, João Luís
dc.contributor.authorAngarten, Vitor
dc.contributor.authorPinto, Rita
dc.contributor.authorSantos, Vanessa
dc.contributor.authorFernhall, Bo
dc.contributor.authorSanta-Clara, Helena
dc.contributor.authorMelo, Xavier
dc.date.accessioned2025-03-17T17:36:44Z
dc.date.available2025-03-17T17:36:44Z
dc.date.issued2025
dc.descriptionCopyright: © 2025 Marôco et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractThe post-exercise hypotension response is controversial among patients with coronary artery disease (CAD). Factors behind this disparity may include post-exercise differential effects on central and brachial blood pressure (BP), exercise intensity and inter-individual variability. Thus, we investigate group and individual central and brachial BP responses 5, 15 and 30-min after combined exercise of different intensities in participants with and without CAD. Seventeen participants with stable CAD and eighteen aged-matched controls (52-81 years) completed an acute bout of high and moderate-intensity combined exercise. Brachial and central systolic (cSBP) pressures were assessed via oscillometry and carotid tonometry, respectively. Central pulse wave velocity was also measured. Group mean changes were examined with linear mixed models, and bSBP and cSBP post-exercise individual responsiveness quantified via the region of practical equivalence and highest density interval, a Bayesian decision rule. Regardless of exercise intensity, cSBP was persistently increased during recovery in participants with CAD (difference 30 -baseline (d30-bas) = 10, 95% CI: 4 to 17 mmHg, p = 0.001) but reduced in controls (d30-bas = -13, 95% CI: -19 to -7 mmHg, p = 0.003). bSBP was unchanged in both groups (CAD: d30-bas = 1, 95% CI: -3 to 6 mmHg, p = 0.995, control: d30-bas = -4, 95% CI: -2 to 8 mmHg, p = 0.999). Most participants with CAD exhibited sustained elevations in cSBP (n = 10), while most controls were post-exercise hypertensive responders (n = 11) with changes >|5| mmHg. We found differential post-exercise effects on central and brachial BP independent from combined exercise intensity but not clinical population. Clinical trials.gov registration ID: NCT06617117.pt_PT
dc.description.sponsorshipThe authors thank FCT/MCTES for the financial support to CiiEM (10.54499/UIDB/04585/2020) through national funds. CiiEM has provided support through Project 10.54499/UIDB/04585/2020, funded by FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2025 Feb 21;20(2):e0317212pt_PT
dc.identifier.doi10.1371/journal.pone.0317212pt_PT
dc.identifier.eissn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.5/99404
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosone/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePost-exercise differential response of central and brachial blood pressure in patients with coronary artery disease: a randomized crossover trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F04585%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.titlePLOS ONEpt_PT
oaire.citation.volume20pt_PT
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
person.familyNameANGARTEN
person.familyNamePinto
person.familyNameSantos
person.familyNameSanta-Clara
person.familyNameMelo
person.givenNameVITOR
person.givenNameRita
person.givenNameVanessa
person.givenNameHelena
person.givenNameXavier
person.identifier1272667
person.identifier.ciencia-id8610-A4F0-88ED
person.identifier.ciencia-idCE1C-5AB1-14B9
person.identifier.ciencia-idD010-C9C5-5147
person.identifier.orcid0000-0002-6916-0737
person.identifier.orcid0000-0003-0925-4245
person.identifier.orcid0000-0003-2540-2826
person.identifier.orcid0000-0003-3134-3893
person.identifier.orcid0000-0003-3934-3986
person.identifier.ridH-3055-2016
person.identifier.ridIQW-2251-2023
person.identifier.ridG-7713-2016
person.identifier.scopus-author-id6506107238
person.identifier.scopus-author-id36613303700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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