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Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammation

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dc.contributor.authorBarvitenko, Nadezhda
dc.contributor.authorAshrafuzzaman, Mohammad
dc.contributor.authorLawen, Alfons
dc.contributor.authorSkverchinskaya, Elisaveta
dc.contributor.authorSaldanha, Carlota
dc.contributor.authorManca, Alessia
dc.contributor.authorUras, Giuseppe
dc.contributor.authorAslam, Muhammad
dc.contributor.authorPantaleo, Antonella
dc.date.accessioned2022-05-03T14:22:13Z
dc.date.available2022-05-03T14:22:13Z
dc.date.issued2022
dc.description© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractChronic low-grade vascular inflammation and endothelial dysfunction significantly contribute to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory or pro-inflammatory signaling can be induced by different patterns of the fluid shear stress (SS) exerted by blood flow on ECs. Laminar blood flow with high magnitude is anti-inflammatory, while disturbed flow and laminar flow with low magnitude is pro-inflammatory. Endothelial mechanosensors are the key upstream signaling proteins in SS-induced pro- and anti-inflammatory responses. Being transmembrane proteins, mechanosensors, not only experience fluid SS but also become regulated by the biomechanical properties of the lipid bilayer and the cytoskeleton. We review the apparent effects of pro-inflammatory factors (hypoxia, oxidative stress, hypercholesterolemia, and cytokines) on the biomechanics of the lipid bilayer and the cytoskeleton. An analysis of the available data suggests that the formation of a vicious circle may occur, in which pro-inflammatory cytokines enhance and attenuate SS-induced pro-inflammatory and anti-inflammatory signaling, respectively.pt_PT
dc.description.sponsorshipThis research was funded by grant from “Fondo di Ateneo per la ricerca 2020”, University of Sassari, Italy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMembranes 2022, 12, 205pt_PT
dc.identifier.doi10.3390/membranes12020205pt_PT
dc.identifier.eissn2077-0375
dc.identifier.urihttp://hdl.handle.net/10451/52659
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/membranespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectCytoskeletonpt_PT
dc.subjectEndothelial cellpt_PT
dc.subjectInflammationpt_PT
dc.subjectLipid bilayerpt_PT
dc.subjectMechanosensorpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectShear stresspt_PT
dc.titleEndothelial cell plasma membrane biomechanics mediates effects of pro-inflammatory factors on endothelial mechanosensors: vicious circle formation in atherogenic inflammationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage205pt_PT
oaire.citation.titleMembranespt_PT
oaire.citation.volume12pt_PT
person.familyNameBarvitenko
person.familyNameAshrafuzzaman
person.familyNameLawen
person.familyNameSkverchinskaya
person.familyNameSaldanha
person.familyNameManca
person.familyNameUras
person.familyNameAslam
person.familyNamePANTALEO
person.givenNameNadezhda
person.givenNameMohammad
person.givenNameAlfons
person.givenNameElisaveta
person.givenNameCarlota
person.givenNameAlessia
person.givenNameGiuseppe
person.givenNameMuhammad
person.givenNameAntonella
person.identifier53901
person.identifier.orcid0000-0002-9866-7545
person.identifier.orcid0000-0002-2882-3821
person.identifier.orcid0000-0001-6553-9945
person.identifier.orcid0000-0001-9587-6619
person.identifier.orcid0000-0002-5058-2112
person.identifier.orcid0000-0001-7342-1023
person.identifier.orcid0000-0003-3494-8521
person.identifier.orcid0000-0001-9026-8219
person.identifier.orcid0000-0003-2954-7053
person.identifier.ridAAU-8675-2020
person.identifier.ridA-6598-2008
person.identifier.ridJ-8514-2018
person.identifier.scopus-author-id57205002523
person.identifier.scopus-author-id7003637699
person.identifier.scopus-author-id8988716300
person.identifier.scopus-author-id57211976489
person.identifier.scopus-author-id57219123417
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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