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Thymic determinants of γδ T cell differentiation

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dc.contributor.authorMuñoz-Ruiz, Miguel
dc.contributor.authorSumaria, Nital
dc.contributor.authorPennington, Daniel J.
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2022-06-08T15:10:01Z
dc.date.available2022-06-08T15:10:01Z
dc.date.issued2017
dc.description© 2017 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractγd T cells have emerged as major sources of the proinflammatory cytokines interleukin-17 (IL-17) and interferon-γ (IFNγ) in multiple models of infection, cancer and autoimmune disease. However, unlike their αβ T cell counterparts that require peripheral activation for effector cell differentiation, γδ T cells instead can be 'developmentally programmed' in the thymus to generate discrete γδ T cell effector subsets with distinctive molecular signatures. Nonetheless, recent studies have presented conflicting viewpoints on the signals involved in thymic γδ T cell development and differentiation, namely on the role of both T cell receptor (TCR)-dependent and TCR-independent factors. Here we review the current data and the ongoing controversies.pt_PT
dc.description.sponsorshipThis work was funded by the European Research Council (CoG_646701) to BS-S, and the Wellcome Trust (Grant Award 092973/Z/10/Z) to DJP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrends Immunol. 2017 May;38(5):336-344pt_PT
dc.identifier.doi10.1016/j.it.2017.01.007pt_PT
dc.identifier.eissn1471-4981
dc.identifier.issn1471-4906
dc.identifier.urihttp://hdl.handle.net/10451/53345
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMicroRNA determinants of the balance between effector and regulatory T cells in vivo
dc.relationUnderstanding T cell receptor (TCR) signalling requirements for thymic gamma/delta cell development; are gamma/delta cells selected through their TCR?.
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/trends-in-immunologypt_PT
dc.subjectIFN-γpt_PT
dc.subjectIL-17pt_PT
dc.subjectT-cell developmentpt_PT
dc.subjectTCRpt_PT
dc.subjectThymuspt_PT
dc.subjectγδ T cellspt_PT
dc.titleThymic determinants of γδ T cell differentiationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicroRNA determinants of the balance between effector and regulatory T cells in vivo
oaire.awardTitleUnderstanding T cell receptor (TCR) signalling requirements for thymic gamma/delta cell development; are gamma/delta cells selected through their TCR?.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/646701/EU
oaire.awardURIinfo:eu-repo/grantAgreement/WT/Immune System in Health and Disease/092973
oaire.citation.endPage344pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage336pt_PT
oaire.citation.titleTrends in Immunologypt_PT
oaire.citation.volume38pt_PT
oaire.fundingStreamH2020
oaire.fundingStreamImmune System in Health and Disease
person.familyNameMuñoz-Ruiz
person.familyNameSilva-Santos
person.givenNameMiguel
person.givenNameBruno
person.identifier1310940
person.identifier.ciencia-idD51E-6517-BE6A
person.identifier.orcid0000-0001-7986-3527
person.identifier.orcid0000-0003-4141-9302
person.identifier.scopus-author-id36070629600
person.identifier.scopus-author-id6505885924
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/100010269
project.funder.nameEuropean Commission
project.funder.nameWellcome Trust
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationf313ff02-41ee-4014-88a1-bd641b6219bf
relation.isAuthorOfPublication.latestForDiscoverye765885f-33ac-400e-988e-4008826ec7bc
relation.isProjectOfPublication938534e5-d56f-4c9b-9984-1e4c262ca6ae
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