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Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus

2021-05Journal article Open access
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dc.contributor.authorCosta, Sofia Santos
dc.contributor.authorFerreira, Carolina
dc.contributor.authorRibeiro, Rute
dc.contributor.authorFessler, Andrea T.
dc.contributor.authorSchink, Anne-Kathrin
dc.contributor.authorKadlec, Kristina
dc.contributor.authorKaspar, Heike
dc.contributor.authorAmaro, Ana
dc.contributor.authorAlbuquerque, Teresa
dc.contributor.authorAbrantes, Patricia
dc.contributor.authorMorais, Catarina
dc.contributor.authorPomba, C.
dc.contributor.authorSchwarz, Stefan
dc.contributor.authorCouto, Isabel
dc.date.accessioned2021-11-09T15:14:48Z
dc.date.available2021-11-09T15:14:48Z
dc.date.issued2021-05
dc.descriptionResearch Areas: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacypt_PT
dc.description.abstractApramycin and florfenicol are two antimicrobial agents exclusively used in veterinary medicine. Resistance determinants to these antimicrobial agents have been described in several staphylococci, yet no inhibition zone-based epidemiological cutoff (ECOFF) values are available to detect populations harboring resistance mechanisms. In this study, we propose disk diffusion inhibition zone ECOFF values of Staphylococcus aureus for apramycin and florfenicol. The susceptibility to apramycin and florfenicol was evaluated by disk diffusion of five S. aureus collections, comprising 352 isolates of animal (n = 265) and human (n = 87) origin. The aggregated distributions of inhibition zone diameters were analyzed by the normalized resistance interpretation method to obtain normalized wild-type (WT) population distributions and corresponding ECOFF values. The putative WT populations of S. aureus were characterized by an inhibition zone ‡15 mm (ECOFF = 15 mm) for apramycin and ‡21 mm for florfenicol (ECOFF = 21 mm). Five nonwild-type (NWT) isolates were detected for apramycin, all without inhibition zone and harboring the apmA gene, whereas five NWT isolates were identified for florfenicol, all carrying the fexA gene. The proposed ECOFF values for apramycin and florfenicol may be a valuable tool in future antimicrobial resistance monitoring and surveillance studies to identify S. aureus NWT populations toward these antimicrobial agents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta SS, Ferreira C, Ribeiro R, Fessler AT, Schink AK, Kadlec K, Kaspar H, Amaro A, Albuquerque T, Pomba C, et al. 2021. Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus. Microbial Drug Resistance, 00(00). DOI:10.1089/mdr.2020.0402pt_PT
dc.identifier.doi10.1089/mdr.2020.0402pt_PT
dc.identifier.eissn1931-8448
dc.identifier.issn1076-6294
dc.identifier.urihttp://hdl.handle.net/10400.5/22537
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebertpt_PT
dc.relationLISBOA-01-0145-FEDER-030713pt_PT
dc.relationUID/04413/2020pt_PT
dc.relation.publisherversionhttps://www.liebertpub.com/doi/pdfplus/10.1089/mdr.2020.0402pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectStaphylococcus aureuspt_PT
dc.subjectEpidemiological cutoff valuept_PT
dc.subjectApramycinpt_PT
dc.subjectFlorfenicolpt_PT
dc.titleProposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FCAL-EST%2F30713%2F2017/PT
oaire.citation.conferencePlaceNew Yorkpt_PT
oaire.citation.titleMicrobial Drug Resistancept_PT
oaire.citation.volume00(00)pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameMatias Ferreira Pomba
person.givenNameMaria Constança
person.identifier.ciencia-idDA1D-20A8-7F3C
person.identifier.orcid0000-0002-0504-6820
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery53f8cdd6-0030-47fd-9881-a78557579f70
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