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Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovir

2023Artigo científico Acesso aberto
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dc.contributor.authorCaria, João
dc.contributor.authorVara-Luiz, Francisco
dc.contributor.authorMaia, Inês
dc.contributor.authorJoosten, Anneke
dc.contributor.authorVal-Flores, Luís
dc.contributor.authorPinheiro, Hélder
dc.contributor.authorPóvoas, Diana
dc.contributor.authorGermano, Nuno
dc.contributor.authorMaltez, Fernando
dc.date.accessioned2023-03-28T13:22:04Z
dc.date.available2023-03-28T13:22:04Z
dc.date.issued2023
dc.description© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractWe report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccination orthopoxviruses in immunosuppressed patients. Severe small bowel involvement jeopardized normal oral tecovirimat and antiretroviral therapy absorption. This problem prompted the use of full parenteral antiretrovirals and endovenous cidofovir. Although a remarkable decrease in HIV viral load occurred in six days, mpox infection continued to progress, and the patient died of septic shock. This case offers new clinical insights on the presentation of severe disease in AIDS patients. Moreover, this case alerts for the need for prompt therapy initiation in patients at risk of ominous clinical progression.pt_PT
dc.description.sponsorshipThe writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant number UIDB/04295/2020 and UIDP/04295/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInfect Dis Rep. 2023 Mar 16;15(2):171-179pt_PT
dc.identifier.doi10.3390/idr15020018pt_PT
dc.identifier.eissn2036-7449
dc.identifier.issn2036-7430
dc.identifier.urihttp://hdl.handle.net/10451/56863
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEnvironmental Health Institute
dc.relationEnvironmental Health Institute
dc.relation.publisherversionhttps://www.mdpi.com/journal/idrpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAIDSpt_PT
dc.subjectHIVpt_PT
dc.subjectCidofovirpt_PT
dc.subjectEnteropathypt_PT
dc.subjectFatalpt_PT
dc.subjectMpoxpt_PT
dc.subjectProgressivept_PT
dc.subjectTecovirimatpt_PT
dc.titleFatal case of progressive Mpox in a patient with AIDS: viral enteropathy and malabsorption demanding the use of full parenteral ARV and endovenous Cidofovirpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04295/2020
oaire.awardNumberUIDP/04295/2020
oaire.awardTitleEnvironmental Health Institute
oaire.awardTitleEnvironmental Health Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04295%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04295%2F2020/PT
oaire.citation.endPage179pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage171pt_PT
oaire.citation.titleInfectious Disease Reportspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMaltez
person.givenNameFernando
person.identifier.orcid0000-0001-5828-7727
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication53585d08-418f-4db3-8ad9-efe8ebedb7a1
relation.isAuthorOfPublication.latestForDiscovery53585d08-418f-4db3-8ad9-efe8ebedb7a1
relation.isProjectOfPublicationcb78892a-90cd-493b-9593-d2bfad27d559
relation.isProjectOfPublicatione1b50370-2ac3-497c-a2c2-72f33f50643e
relation.isProjectOfPublication.latestForDiscoverycb78892a-90cd-493b-9593-d2bfad27d559

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