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Depressive symptoms and amyloid pathology

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dc.contributor.authorWiels, Wietse A.
dc.contributor.authorOomens, Julie E.
dc.contributor.authorEngelborghs, Sebastiaan
dc.contributor.authorBaeken, Chris
dc.contributor.authorvon Arnim, Christine A.F.
dc.contributor.authorBoada, Mercè
dc.contributor.authorDidic, Mira
dc.contributor.authorDubois, Bruno
dc.contributor.authorFladby, Tormod
dc.contributor.authorvan der Flier, Wiesje M.
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorFröhlich, Lutz
dc.contributor.authorGill, Kiran Dip
dc.contributor.authorGrimmer, Timo
dc.contributor.authorHildebrandt, Helmut
dc.contributor.authorHort, Jakub
dc.contributor.authorItoh, Yoshiaki
dc.contributor.authorIwatsubo, Takeshi
dc.contributor.authorKlimkowicz-Mrowiec, Aleksandra
dc.contributor.authorLee, Dong Young
dc.contributor.authorLleó, Alberto
dc.contributor.authorMartinez-Lage, Pablo
dc.contributor.authorDe Mendonça, Alexandre
dc.contributor.authorMeyer, Philipp T.
dc.contributor.authorKapaki, Elisabeth N.
dc.contributor.authorParchi, Piero
dc.contributor.authorPardini, Matteo
dc.contributor.authorParnetti, Lucilla
dc.contributor.authorPopp, Julius
dc.contributor.authorRami, Lorena
dc.contributor.authorReiman, Eric M.
dc.contributor.authorRinne, Juha O.
dc.contributor.authorRodrigue, Karen M.
dc.contributor.authorSánchez-Juan, Pascual
dc.contributor.authorSantana, Isabel
dc.contributor.authorSarazin, Marie
dc.contributor.authorScarmeas, Nikolaos
dc.contributor.authorSkoog, Ingmar
dc.contributor.authorSnyder, Peter J.
dc.contributor.authorSperling, Reisa A.
dc.contributor.authorVilleneuve, Sylvia
dc.contributor.authorWallin, Anders
dc.contributor.authorWiltfang, Jens
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorOssenkoppele, Rik
dc.contributor.authorVerhey, Frans R. J.
dc.contributor.authorVos, Stephanie J. B.
dc.contributor.authorVisser, Pieter Jelle
dc.contributor.authorJansen, Willemijn J.
dc.contributor.authorAlcolea, Daniel
dc.contributor.authorAltomare, Daniele
dc.contributor.authorBaiardi, Simone
dc.contributor.authorBaldeiras, Ines
dc.contributor.authorBateman, Randall J.
dc.contributor.authorBlennow, Kaj
dc.contributor.authorBottlaender, Michel
dc.contributor.authorden Braber, Anouk
dc.contributor.authorvan Buchem, Mark A.
dc.contributor.authorByun, Min Soo
dc.contributor.authorCerman, Jiří
dc.contributor.authorChen, Kewei
dc.contributor.authorChipi, Elena
dc.contributor.authorDay, Gregory S.
dc.contributor.authorDrzezga, Alexander
dc.contributor.authorEckerström, Marie
dc.contributor.authorEkblad, Laura L.
dc.contributor.authorEpelbaum, Stéphane
dc.contributor.authorFörster, Stefan
dc.contributor.authorFortea, Juan
dc.contributor.authorFreund-Levi, Yvonne
dc.contributor.authorFrings, Lars
dc.contributor.authorGuedj, Eric
dc.contributor.authorHausner, Lucrezia
dc.contributor.authorHellwig, Sabine
dc.contributor.authorHuey, Edward D.
dc.contributor.authorJiménez-Bonilla, Julio F.
dc.contributor.authorJohnson, Keith A.
dc.contributor.authorJuaristi, Ane Iriondo
dc.contributor.authorKandimalla, Ramesh
dc.contributor.authorParaskevas, George
dc.contributor.authorKern, Silke
dc.contributor.authorKirsebom, Bjørn-Eivind S.
dc.contributor.authorKornhuber, Johannes
dc.contributor.authorLagarde, Julien
dc.contributor.authorLandau, Susan M.
dc.contributor.authorLegdeur, Nienke
dc.contributor.authorLlibre Guerra, Jorge J.
dc.contributor.authorMaserejian, Nancy N.
dc.contributor.authorMarquié, Marta
dc.contributor.authorMinatani, Shinobu
dc.contributor.authorMorbelli, Silvia Daniela
dc.contributor.authorMroczko, Barbara
dc.contributor.authorNtanasi, Eva
dc.contributor.authorde Oliveira, Catarina Resende
dc.contributor.authorOlivieri, Pauline
dc.contributor.authorOrellana, Adelina
dc.contributor.authorPerrin, Richard J.
dc.contributor.authorPeters, Oliver
dc.contributor.authorPrabhakar, Sudesh
dc.contributor.authorRamakers, Inez H.
dc.contributor.authorRodríguez-Rodriguez, Eloy
dc.contributor.authorRuiz, Agustín
dc.contributor.authorRüther, Eckart
dc.contributor.authorSelnes, Per
dc.contributor.authorSilva, Dina
dc.contributor.authorSoininen, Hilkka
dc.contributor.authorSpiru, Luiza
dc.contributor.authorTakeda, Akitoshi
dc.contributor.authorTeichmann, Marc
dc.contributor.authorTijms, Betty M.
dc.contributor.authorTeunissen, Charlotte E.
dc.contributor.authorThompson, Loisa I.
dc.contributor.authorVogelgsangs, Jonathan
dc.contributor.authorVöglein, Jonathan
dc.contributor.authorWaldemar, Gunhild
dc.contributor.authorWallin, Åsa K.
dc.contributor.authorYannakoulia, Mary
dc.contributor.authorYi, Dahyun
dc.contributor.authorZettergren, Anna
dc.date.accessioned2025-02-04T12:12:02Z
dc.date.available2025-02-04T12:12:02Z
dc.date.issued2025
dc.description© 2025 American Medical Association. All rights reserved, including those for text and data mining, AI training, and similar technologiespt_PT
dc.description.abstractImportance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia. Design, setting, and participants: Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024. Main outcomes and measures: Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms. Results: In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2%] female; 3002 [34.0%] APOE ε4 carriers; 937 [9.6%] had depressive symptoms; 2648 [27.2%] had amyloid pathology), the presence of depressive symptoms was not associated with amyloid pathology (odds ratio [OR], 1.13; 95% CI, 0.90-1.40; P = .29). In individuals with MCI (mean [SD] age, 70.2 [8.7] years; 1481 [49.0%] female; 1046 [44.8%] APOE ε4 carriers; 824 [27.3%] had depressive symptoms; 1668 [55.8%] had amyloid pathology), the presence of depressive symptoms was associated with a lower likelihood of amyloid pathology (OR, 0.73; 95% CI 0.61-0.89; P = .001). When considering subgroup effects, in individuals with NC, the presence of depressive symptoms was associated with a higher frequency of amyloid pathology in APOE ε4 noncarriers (mean difference, 5.0%; 95% CI 1.0-9.0; P = .02) but not in APOE ε4 carriers. This was not the case in individuals with MCI. Conclusions and relevance: Depressive symptoms were not consistently associated with a higher frequency of amyloid pathology in participants with NC and were associated with a lower likelihood of amyloid pathology in participants with MCI. These findings were not influenced by age, sex, or education level. Mechanisms other than amyloid accumulation may commonly underlie depressive symptoms in late life.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJAMA Psychiatry. 2025 Jan 22. doi: 10.1001/jamapsychiatry.2024.4305pt_PT
dc.identifier.doi10.1001/jamapsychiatry.2024.4305pt_PT
dc.identifier.eissn2168-6238
dc.identifier.issn2168-622X
dc.identifier.urihttp://hdl.handle.net/10400.5/98075
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Medical Association.pt_PT
dc.relation.publisherversionhttps://jamanetwork.com/journals/jamapsychiatrypt_PT
dc.titleDepressive symptoms and amyloid pathologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJAMA Psychiatrypt_PT
person.familyNamede Mendonça
person.familyNameSilva
person.givenNameAlexandre
person.givenNameDina
person.identifier.ciencia-id1615-41B4-0848
person.identifier.orcid0000-0002-0488-1453
person.identifier.orcid0000-0003-4437-2765
person.identifier.scopus-author-id7003320823
person.identifier.scopus-author-id26657734400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication53ca3547-99ce-4b68-9330-7879a54c47b7
relation.isAuthorOfPublicationb5337ee0-499f-46bb-bb3f-c72bc640dd57
relation.isAuthorOfPublication.latestForDiscoveryb5337ee0-499f-46bb-bb3f-c72bc640dd57

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