Repository logo
 
Publication

Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis

2022Journal article Open access
Simple item page
dc.contributor.authorDe Niz, Mariana
dc.contributor.authorSilva Pereira, Sara
dc.contributor.authorSerre, Karine
dc.contributor.authorOuarné, Marie
dc.contributor.authorCoelho, Joana E
dc.contributor.authorFranco, Claudio
dc.contributor.authorFigueiredo, Luisa M.
dc.date.accessioned2022-12-14T12:01:28Z
dc.date.available2022-12-14T12:01:28Z
dc.date.issued2022
dc.description© 2022, Silva Pereira, De Niz et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.pt_PT
dc.description.abstractTrypanosoma congolense causes a syndrome of variable severity in animals in Africa. Cerebral trypanosomiasis is a severe form, but the mechanism underlying this severity remains unknown. We developed a mouse model of acute cerebral trypanosomiasis and characterized the cellular, behavioral, and physiological consequences of this infection. We show large parasite sequestration in the brain vasculature for long periods of time (up to 8 hr) and extensive neuropathology that associate with ICAM1-mediated recruitment and accumulation of T cells in the brain parenchyma. Antibody-mediated ICAM1 blocking and lymphocyte absence reduce parasite sequestration in the brain and prevent the onset of cerebral trypanosomiasis. Here, we establish a mouse model of acute cerebral trypanosomiasis and we propose a mechanism whereby parasite sequestration, host ICAM1, and CD4+ T cells play a pivotal role.pt_PT
dc.description.sponsorshipThis work was supported by European Union’s Horizon 2020 research and innovation program through a Marie Skłodowska-Curie Individual Standard European Fellowship to S.S.P., under grant agreement no. 839960, and from the European Research Council (ERC) (FatTryp, 771714) to L.M.F. M.D.N. was funded by Human Frontiers LT000047/2019 L (HFSP) and EMBO (ALTF 1048–2016). L.M.F., K.S., and C.A.F. are Investigators CEEC of the Fundação para a Ciência e a Tecnologia (CEECIND/03322/2018, CEECIND/00697/2018, CEECIND/04251/2017, respectively). C.A.F. was supported by a European Research Council starting grant (679368), the Fondation Leducq (17CVD03), and the Fundação para a Ciência e a Tecnologia (grants IF/00412/2012, EXPL/BEX- BCM/2258/2013, PRECISE-LISBOA-01–0145-FEDER-016394, PTDC/MED-PAT/31639/2017, PTDC/BIA-CEL/32180/2017).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationElife. 2022 Jul 5;11:e77440pt_PT
dc.identifier.doi10.7554/eLife.77440pt_PT
dc.identifier.eissn2050-084X
dc.identifier.urihttp://hdl.handle.net/10451/55386
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publishereLife Sciences Publicationspt_PT
dc.relationPRECISE-LISBOA-01-0145-FEDER-016394pt_PT
dc.relationCharacterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins
dc.relationExploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relationPRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING
dc.relationDeregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy
dc.relationIdentify the mechanisms of endothelial tip cell invasive behavior in order to inhibit physiological and pathological sprouting angiogenesis
dc.relation.publisherversionhttps://elifesciences.org/subjects/microbiology-infectious-diseasept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTrypanosoma congolensept_PT
dc.subjectCerebral trypanosomiasispt_PT
dc.subjectInfectious diseasept_PT
dc.subjectMicrobiologypt_PT
dc.subjectNaganapt_PT
dc.subjectSequestrationpt_PT
dc.subjectVirulencept_PT
dc.titleImmunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCharacterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins
oaire.awardTitleExploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitlePRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING
oaire.awardTitleDeregulated Endothelial Blood Flow Response as a cause of Diabetic Retinopathy
oaire.awardTitleIdentify the mechanisms of endothelial tip cell invasive behavior in order to inhibit physiological and pathological sprouting angiogenesis
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/839960/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/771714/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F03322%2F2018%2FCP1543%2FCT0009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00697%2F2018%2FCP1543%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F04251%2F2017%2FCP1396%2FCT0010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/679368/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00412%2F2012%2FCP0163%2FCT0007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBEX-BCM%2F2258%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-PAT%2F31639%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-CEL%2F32180%2F2017/PT
oaire.citation.titleeLifept_PT
oaire.citation.volume11pt_PT
oaire.fundingStreamH2020
oaire.fundingStreamH2020
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamH2020
oaire.fundingStreamInvestigador FCT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameDe Niz
person.familyNameSilva Pereira
person.familyNameSerre
person.familyNameOuarné
person.familyNameCoelho
person.familyNameFranco
person.familyNameFigueiredo
person.givenNameMariana
person.givenNameSara
person.givenNameKarine
person.givenNameMarie
person.givenNameJoana
person.givenNameClaudio
person.givenNameLuisa M
person.identifier1058659
person.identifier120366
person.identifierD-8117-2015
person.identifier.ciencia-id8B17-CF8D-E8CD
person.identifier.ciencia-id1E11-7283-DF35
person.identifier.ciencia-id5812-BBB8-51A4
person.identifier.ciencia-idB310-839B-564D
person.identifier.ciencia-idF012-B7D6-AE72
person.identifier.ciencia-id421C-420D-E7BD
person.identifier.orcid0000-0001-6987-6789
person.identifier.orcid0000-0002-6590-6626
person.identifier.orcid0000-0001-9152-4739
person.identifier.orcid0000-0003-4724-4363
person.identifier.orcid0000-0002-3964-6197
person.identifier.orcid0000-0002-2861-3883
person.identifier.orcid0000-0002-5752-6586
person.identifier.scopus-author-id6602493849
person.identifier.scopus-author-id7101840699
person.identifier.scopus-author-id24280736600
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationee699259-c8eb-4f2d-9646-32608e67e531
relation.isAuthorOfPublication1aef6355-38a9-4ce5-9f2c-ac3beb8fee9e
relation.isAuthorOfPublicationca6a906a-8017-40b3-9692-8c72c063c339
relation.isAuthorOfPublicationb9e2fe55-d7bd-4433-8cee-6457f2846bfe
relation.isAuthorOfPublication1301afd3-8056-4d54-983c-0bec935b2d75
relation.isAuthorOfPublication633fb0a6-1f81-4d35-98ca-b4cfd838d81e
relation.isAuthorOfPublication996632d8-b4b7-45ab-903f-aec092718a0d
relation.isAuthorOfPublication.latestForDiscoveryb9e2fe55-d7bd-4433-8cee-6457f2846bfe
relation.isProjectOfPublication84f48bb7-1826-461d-a2e7-86af03859526
relation.isProjectOfPublicationa129aa83-6d3e-4f27-a015-1842a6bd7ea0
relation.isProjectOfPublicationed2e90f0-41eb-43a3-9a57-7b391e2052b7
relation.isProjectOfPublication30b9e700-dc83-4c72-bef7-a9cec1bccb83
relation.isProjectOfPublication392c79be-8d7a-4bc6-8326-622a2f5fc48a
relation.isProjectOfPublication5b819576-166d-4a04-9a0e-d37f9af3ec67
relation.isProjectOfPublication1410e345-5bc6-4542-a944-bab6d602a249
relation.isProjectOfPublication468b1579-b2c1-489e-a8ca-7f98cd803489
relation.isProjectOfPublication6ae76ccd-c68c-440c-82ad-ddde57bf1822
relation.isProjectOfPublicationee6edd62-17fc-409b-ad2c-1ef8d02ac491
relation.isProjectOfPublication.latestForDiscoverya129aa83-6d3e-4f27-a015-1842a6bd7ea0

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Trypanosoma_congolense.pdf
Size:
10.61 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais