Camelized rabbit-derived VH single-domain Intrabodies Against vif strongly neutralize HIV-1 infectivity

da Silva, FA; Santa-Marta, M; Freitas-Vieira, A; Mascarenhas, P; Barahona, I; Moniz-Pereira, J; Gabuzda, D; Goncalves, J

http://hdl.handle.net/10451/21600

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Abstract(s)

We recently developed a specific single-chain antibody from immunized rabbits to HIV-1 Vif protein that was expressed intracellularly and inhibited reverse transcription and viral replication. The Vif of HIV-1 overcomes the innate antiviral activity of a