Battle of the γδ T cell subsets in the gut

Mensurado, Sofia; Silva-Santos, Bruno

http://hdl.handle.net/10451/54843

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Autores

Mensurado, Sofia

Silva-Santos, Bruno

Resumo(s)

In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17+ γδ T cell subsets that promote its growth.