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Plasmatic Klotho and FGF23 levels as biomarkers of CKD-associated cardiac disease in type 2 diabetic patients

2019Journal article Open access
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dc.contributor.authorSilva, Ana
dc.contributor.authorMendes, Filipa
dc.contributor.authorCarias, Eduarda
dc.contributor.authorGonçalves, Rui
dc.contributor.authorFragoso, André
dc.contributor.authorDias, Carolina
dc.contributor.authorTavares, Nelson
dc.contributor.authorCafé, Hugo
dc.contributor.authorSantos, Nélio
dc.contributor.authorRato, Fátima
dc.contributor.authorLeão Neves, Pedro
dc.contributor.authorAlmeida, Edgar
dc.date.accessioned2022-09-05T13:44:39Z
dc.date.available2022-09-05T13:44:39Z
dc.date.issued2019
dc.description© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractBackground: Research over the past decade has focused on the role of Klotho as a cardio protective agent that prevents the effects of aging on the heart and reduces the burden of cardiovascular disease CVD. The role of the interaction between fibroblast growth factor 23-(FGF-23)/Klotho in Klotho-mediated actions is still under debate. The main objective was to ascertain the potential use of plasmatic Klotho and FGF23 as markers for CKD-associated cardiac disease and mortality. Methods: This was a prospective analysis conducted in an outpatient diabetic nephropathy clinic, enrolling 107 diabetic patients with stage 2⁻3 CKD. Patients were divided into three groups according to their left ventricular mass index and relative wall thickness. Results: Multinomial regression analysis demonstrated that low Klotho and higher FGF-23 levels were linked to a greater risk of concentric hypertrophy. In the generalized linear model (GLM), Klotho, FGF-23 and cardiac geometry groups were statistically significant as independent variables of cardiovascular hospitalization (p = 0.007). According to the Cox regression model, fatal cardiovascular events were associated with the following cardiac geometric classifications; eccentric hypertrophy (p = 0.050); concentric hypertrophy (p = 0.041), and serum phosphate ≥ 3.6 mg/dL (p = 0.025), FGF-23 ≥ 168 (p = 0.0149), α-klotho < 313 (p = 0.044). Conclusions: In our population, Klotho and FGF23 are associated with cardiovascular risk in the early stages of CKD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Mol Sci. 2019 Mar 27;20(7):1536pt_PT
dc.identifier.doi10.3390/ijms20071536pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10451/54303
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/20/7/1536/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCKDpt_PT
dc.subjectCVDpt_PT
dc.subjectFGF-23pt_PT
dc.subjectLVMIpt_PT
dc.subjectklothopt_PT
dc.titlePlasmatic Klotho and FGF23 levels as biomarkers of CKD-associated cardiac disease in type 2 diabetic patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume20pt_PT
person.familyNameFernandes de Almeida
person.givenNameEdgar Avito
person.identifier.ciencia-id4910-CDF1-B27A
person.identifier.orcid0000-0003-0702-4569
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication24a175d4-d3d9-49a0-8668-364358714e76
relation.isAuthorOfPublication.latestForDiscovery24a175d4-d3d9-49a0-8668-364358714e76

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