Publication
Disease mechanisms in preclinical rheumatoid arthritis: a narrative review
| dc.contributor.author | Romão, Vasco C. | |
| dc.contributor.author | Fonseca, João Eurico | |
| dc.date.accessioned | 2023-06-07T14:25:41Z | |
| dc.date.available | 2023-06-07T14:25:41Z | |
| dc.date.issued | 2022 | |
| dc.description | Copyright © 2022 Romão and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | pt_PT |
| dc.description.abstract | In the last decades, the concept of preclinical rheumatoid arthritis (RA) has become established. In fact, the discovery that disease mechanisms start years before the onset of clinical RA has been one of the major recent insights in the understanding of RA pathogenesis. In accordance with the complex nature of the disease, preclinical events extend over several sequential phases. In a genetically predisposed host, environmental factors will further increase susceptibility for incident RA. In the initial steps of preclinical disease, immune disturbance mechanisms take place outside the joint compartment, namely in mucosal surfaces, such as the lung, gums or gut. Herein, the persistent immunologic response to altered antigens will lead to breach of tolerance and trigger autoimmunity. In a second phase, the immune response matures and is amplified at a systemic level, with epitope spreading and widening of the autoantibody repertoire. Finally, the synovial and bone compartment are targeted by specific autoantibodies against modified antigens, initiating a local inflammatory response that will eventually culminate in clinically evident synovitis. In this review, we discuss the elaborate disease mechanisms in place during preclinical RA, providing a broad perspective in the light of current evidence. | pt_PT |
| dc.description.sponsorship | VCR work was funded by Fundação para a Ciência e Tecnologia (Interno Doutorando Bursary reference SFRH/SINTD/95030/2013); European League Against Rheumatism (EULAR Scientific Training Bursary 2014); and Sociedade Portuguesa de Reumatologia (Fundo de Apoio à Investigação da SPR 2015 & 2016 to VCR). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Front Med (Lausanne). 2022 Aug 19;9:689711 | pt_PT |
| dc.identifier.doi | 10.3389/fmed.2022.689711 | pt_PT |
| dc.identifier.eissn | 2296-858X | |
| dc.identifier.uri | http://hdl.handle.net/10451/58074 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Frontiers | pt_PT |
| dc.relation | SYNOVIAL PATHOBIOLOGY AND PATIENT STRATIFICATION IN RHEUMATOID ARTHRITIS | |
| dc.relation.publisherversion | https://www.frontiersin.org/journals/medicine | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Pre-RA | pt_PT |
| dc.subject | Etiology | pt_PT |
| dc.subject | Pathogenesis | pt_PT |
| dc.subject | Preclinical rheumatoid arthritis | pt_PT |
| dc.subject | Rheumatoid arthritis | pt_PT |
| dc.title | Disease mechanisms in preclinical rheumatoid arthritis: a narrative review | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | SYNOVIAL PATHOBIOLOGY AND PATIENT STRATIFICATION IN RHEUMATOID ARTHRITIS | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FSINTD%2F95030%2F2013/PT | |
| oaire.citation.title | Frontiers in Medicine | pt_PT |
| oaire.citation.volume | 9 | pt_PT |
| person.familyName | C Romão | |
| person.familyName | Fonseca | |
| person.givenName | Vasco | |
| person.givenName | João | |
| person.identifier | 490119 | |
| person.identifier.ciencia-id | 771D-0A5C-626B | |
| person.identifier.ciencia-id | F310-B85D-57C7 | |
| person.identifier.orcid | 0000-0002-5603-9436 | |
| person.identifier.orcid | 0000-0003-1432-3671 | |
| person.identifier.rid | O-8224-2014 | |
| person.identifier.scopus-author-id | 55989452300 | |
| person.identifier.scopus-author-id | 7101983519 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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