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Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
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Orientador(es)
Resumo(s)
Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations.
Descrição
Palavras-chave
Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis
Contexto Educativo
Citação
Santos F, Pires D, Anes E, Duarte ARC. Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy. International Journal of Pharmaceutics [Internet]. 25 de abril de 2023;637:122862. Disponível em: https://www.sciencedirect.com/science/article/pii/S037851732300282X
Editora
Elsevier