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The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells

2022-06Artigo científico Acesso aberto
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dc.contributor.authorJasiński, Tomasz
dc.contributor.authorZdrojkowski, Łukasz
dc.contributor.authorKautz, Ewa
dc.contributor.authorJuszczuk- Kubiak, Edyta
dc.contributor.authorFerreira-Dias, Graça
dc.contributor.authorDomino, Małgorzata
dc.date.accessioned2022-08-31T09:19:36Z
dc.date.available2022-08-31T09:19:36Z
dc.date.issued2022-06
dc.descriptionResearch Areas: Agriculture ; Reproductive Biology ; Veterinary Sciencespt_PT
dc.description.abstractABSTRACT: Endometritis is an important issue decreasing mares' fertility. In the case of endo-metritis, both inflammatory cells infiltration and proinflammatory molecules produc-tion are regulated by various cellular and gene regulatory mechanisms, including the nuclear factor- κB (NF- κB)- dependent pathway. NF- κB- signalling pathway has been recently studied in the equine endometrium in the context of endometrosis. Thus, this study aimed to determine gene transcription of NF- κB subunits (RelA; NF- κB1; NF- κB2), proinflammatory molecules (M C P - 1 ; I L- 6) and hyaluronan synthases (HAS 1; HAS 2; HAS 3) in endometritis and compare them with the intensity and type of inflamma-tory cell infiltration. Endometrial samples, collected post- mortem from cyclic mares in oestrus or dioestrus, were classified histologically and examined using quantitative PCR. Transcription NF- κB subunits genes did not differ with either inflammatory in-tensity or type of inflammatory cell infiltration. Transcription of M C P - 1 and I L- 6 genes increased with the severity of inflammation, with the involvement of HAS 3 and HAS 2 genes, as opposed to HAS 1 genes. These proinflammatory molecules and hyaluronan synthases in the equine inflamed endometrium do not seem to be regulated by the NF- κB pathway. Hence, separate signalling pathways for the development and pro-gression of equine endometritis and endometrosis may be suggestedpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJasiński T, Zdrojkowski Ł, Kautz E, Juszczuk- Kubiak E, Ferreira-Dias G, Domino M. 2022. The NF- κB- signalling pathway in mare's endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals, 57(6):598–610. DOI: https://doi.org/10.1111/rda.14099pt_PT
dc.identifier.doihttps://doi.org/10.1111/rda.14099pt_PT
dc.identifier.eissn1439-0531
dc.identifier.issn0936-6768
dc.identifier.urihttp://hdl.handle.net/10400.5/25304
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationNational Science Centre, Polandpt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/rda.14099pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEndometritispt_PT
dc.subjectHASpt_PT
dc.subjectIL-6pt_PT
dc.subjectMarept_PT
dc.subjectMCP-1pt_PT
dc.subjectNF-kappa Bpt_PT
dc.titleThe NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceHoboken, NJpt_PT
oaire.citation.endPage610pt_PT
oaire.citation.startPage598pt_PT
oaire.citation.titleReproduction in Domestic Animalspt_PT
oaire.citation.volume57(6)pt_PT
person.familyNameLeitão Ferreira-Dias
person.givenNameGraça Maria
person.identifier.ciencia-idF51C-7F45-C720
person.identifier.orcid0000-0003-0622-6513
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0fb8ec33-7ee1-482b-bdcb-eff773226f90
relation.isAuthorOfPublication.latestForDiscovery0fb8ec33-7ee1-482b-bdcb-eff773226f90

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