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Studying DNA double-strand break repair: an ever-growing toolbox

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dc.contributor.authorVítor, Alexandra
dc.contributor.authorHuertas, Pablo
dc.contributor.authorLegube, Gaëlle
dc.contributor.authorde Almeida, Sérgio F.
dc.date.accessioned2021-07-23T13:03:15Z
dc.date.available2021-07-23T13:03:15Z
dc.date.issued2020
dc.descriptionCopyright © 2020 Vítor, Huertas, Legube and de Almeida. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractTo ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to their repair. Collectively, these signaling networks comprise the DNA damage response (DDR). The current knowledge of the molecular determinants and mechanistic details of the DDR owes greatly to the continuous development of ground-breaking experimental tools that couple the controlled induction of DSBs at distinct genomic positions with assays and reporters to investigate DNA repair pathways, their impact on other DNA-templated processes and the specific contribution of the chromatin environment. In this review, we present these tools, discuss their pros and cons and illustrate their contribution to our current understanding of the DDR.pt_PT
dc.description.sponsorshipWork in the SA lab was funded by PTDC/BIM-ONC/0016/2014 and PTDC/BIA-MOL/30438/2017 from Fundação para a Ciência e a Tecnologia (FCT), Portugal; by LISBOA-01-0145-FEDER-007391, project co-funded by FEDER through POR Lisboa, Portugal 2020–Programa Operacional Regional de Lisboa, and FCT; and by the IMM-Laço Fund. The GL laboratory was funded by grants from the European Research Council (ERC-2014-CoG 647344), Agence Nationale pour la Recherche (ANR-18-CE12-0015-02), the Institut National contre le Cancer (INCA), and the Ligue Nationale contre le Cancer (LNCC).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Mol Biosci. 2020 Feb 21;7:24.pt_PT
dc.identifier.doi10.3389/fmolb.2020.00024pt_PT
dc.identifier.eissn2296-889X
dc.identifier.urihttp://hdl.handle.net/10451/49083
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationLISBOA-01-0145-FEDER-007391pt_PT
dc.relationChromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI
dc.relation.publisherversionhttps://www.frontiersin.org/journals/molecular-biosciencespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDNA damagept_PT
dc.subjectDNA repairpt_PT
dc.subjectChromatinpt_PT
dc.subjectHomologous recombination (HR)pt_PT
dc.subjectNon-homologous DNA end joiningpt_PT
dc.titleStudying DNA double-strand break repair: an ever-growing toolboxpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/BIM-ONC/0016/2014
oaire.awardNumberPTDC/BIA-MOL/30438/2017
oaire.awardNumber647344
oaire.awardTitleChromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-ONC%2F0016%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-MOL%2F30438%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/647344/EU
oaire.citation.titleFrontiers in Molecular Biosciencespt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamH2020
person.familyNameVítor
person.familyNameFERNANDES DE ALMEIDA
person.givenNameAlexandra
person.givenNameSÉRGIO ALEXANDRE
person.identifier.ciencia-id7D18-F40F-7CC1
person.identifier.orcid0000-0002-6178-3980
person.identifier.orcid0000-0002-7774-1355
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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