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Avaliação da presença de lesão renal e de peritonite em cadelas com piómetra
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A piómetra é uma doença de diestro comum em cadelas adultas intactas. Esta está associada a uma grande variedade de sinais clínicos e laboratoriais e frequentemente surgem complicações. Entre elas encontram-se a peritonite, a infeção do trato urinário (ITU) e a lesão renal. Um dos objetivos deste estudo foi avaliar a frequência destas complicações e contribuir para a sua deteção precoce. Um total de 28 cadelas com diagnóstico confirmado de piómetra foi incluído neste trabalho. Escherichia coli foi a bactéria isolada em 16 dos casos (57,1%), e nos restantes 12 foram isoladas outras bactérias (42,9%). Verificou-se a presença de peritonite em 25%, ITU em 21,4% e alteração da função renal em 46,4%. A presença de peritonite foi associada a valores normais de leucócitos totais e ao aumento do período de hospitalização pós-cirúrgico. A utilização de SDMA como marcador de lesão renal precoce demonstrou ser extremamente útil em cadelas com piómetra. Sendo E. coli o agente mais frequentemente isolado em cadelas com piómetra, um outro objetivo passou por caracterizar a estrutura populacional de E. coli presente na microbiota fecal, uterina, urinária e extra-uterina. Foram obtidos um total de 383 isolados dos quais 160 foram de origem uterina, 35 provenientes de amostras de urina, 42 de amostras extra- uterinas e 146 origem fecal. Independentemente da origem dos isolados, o grupo filogenético mais prevalente foi o grupo B2 (89%). A média de clones de E. coli por cadela foi de 1,25 e 81,3% das cadelas tinha apenas um clone do GF B2, comum a todos os locais de colheita em que o isolamento foi positivo.
ABSTRACT - Evaluation of renal disfunction and peritonitis in female dogs with pyometra - Pyometra is a common uterine disease diagnosed during diestrous in intact adult bitches. It is associated with a wide variety of clinical and laboratory findings and complications are often observed. These include peritonitis, urinary tract infection (UTI), and renal damage. One aim of this study was to evaluate the frequency of these complications and to contribute to their early detection. A total of 28 bitches with confirmed pyometra diagnosis were included in this study. Escherichia coli (57.1%) was isolated in 16 cases and in the remaining 12 other bacterias were isolated (42.9%). The presence of peritonitis was found in 25%, UTI in 21.4% and renal lesion in 46.4%. The presence of peritonitis was associated with normal values of total leukocytes and with the increase of post-surgical hospitalization. The use of SDMA as a marker of early renal damage has proved extremely useful in bitches with pyometra. Since E. coli is the most frequent agent identified in bitches with pyometra, another aim was to characterize E. coli population structure present in the fecal, uterine, urinary and extrauterine microbiota. A total of 383 isolates were obtained, of which 160 were from uterine origin, 35 from urine samples, 42 from extrauterine samples and 142 from fecal origin. Independently of the origin of the isolates, the most prevalent phylogenetic group was group B2 (89%). The average of E. coli clones per bitch was 1.25 and 81.3% of the bitches had only one B2 clone, common to all sources of samples where isolation was positive.
ABSTRACT - Evaluation of renal disfunction and peritonitis in female dogs with pyometra - Pyometra is a common uterine disease diagnosed during diestrous in intact adult bitches. It is associated with a wide variety of clinical and laboratory findings and complications are often observed. These include peritonitis, urinary tract infection (UTI), and renal damage. One aim of this study was to evaluate the frequency of these complications and to contribute to their early detection. A total of 28 bitches with confirmed pyometra diagnosis were included in this study. Escherichia coli (57.1%) was isolated in 16 cases and in the remaining 12 other bacterias were isolated (42.9%). The presence of peritonitis was found in 25%, UTI in 21.4% and renal lesion in 46.4%. The presence of peritonitis was associated with normal values of total leukocytes and with the increase of post-surgical hospitalization. The use of SDMA as a marker of early renal damage has proved extremely useful in bitches with pyometra. Since E. coli is the most frequent agent identified in bitches with pyometra, another aim was to characterize E. coli population structure present in the fecal, uterine, urinary and extrauterine microbiota. A total of 383 isolates were obtained, of which 160 were from uterine origin, 35 from urine samples, 42 from extrauterine samples and 142 from fecal origin. Independently of the origin of the isolates, the most prevalent phylogenetic group was group B2 (89%). The average of E. coli clones per bitch was 1.25 and 81.3% of the bitches had only one B2 clone, common to all sources of samples where isolation was positive.
Descrição
Dissertação de Mestrado Integrado em Medicina Veterinária
Palavras-chave
Piómetra Peritonite Lesão renal Escherichia coli Pyometra Peritonitis Renal damage
Contexto Educativo
Citação
Martins, A.P.G. (2019). Avaliação da presença de lesão renal e de peritonite em cadelas com piómetra. Dissertação de mestrado. Universidade de Lisboa, Faculdade de Medicina Veterinária, Lisboa.
Editora
Universidade de Lisboa, Faculdade de Medicina Veterinária