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Uma perspetiva complementar : PANDAS : perturbação neuropsiquiátrica auto-imune pediátrica associada a streptococcus
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Resumo(s)
Em 1998, Sweedo, apercebeu-se que existiam algumas crianças que sofriam com sintomatologia obsessivo-compulsiva associada ainda a tiques. Este era um grupo que se separava das crianças com POC primária e Perturbação de tiques isolada, já que neste grupo parecia existir um início bastante abrupto da sintomatologia, estando esta associada ainda a uma infeção anterior por Streptococcus do grupo A. Intrigada, decide iniciar um estudo com 50 crianças para verificar se esta relação não seria mesmo uma associação causal e não uma mera coincidência. Assim nasce o conceito de PANDAS, um acrónimo para Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections.
Este artigo visa abordar de uma forma concisa e de fácil compreensão toda a evolução do conceito de PANDAS, a sua base fisiopatológica autoimune, o seu diagnóstico, o seu tratamento e ainda as suas variantes.
In 1998, Sweedo realized that there were some children suffering with obsessive-compulsive symptomatology and also with tics. This was a group of kids completely different from the ones that had the primary diagnose of OCD and Tics Disorders, since in this group there seemed to be a rather abrupt onset of symptoms, which was still associated with a previous infection by group A Streptococcus. Intrigued with this, Sweedo decides to start a study to see if this was just a coincidence or if the infections led to the beginning of the symptoms. That’s how PANDAS was born, an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections. This article aims to approach in a concise and easily way all the evolution of PANDAS’ concept, the autoimmune pathophysiological basis, the diagnosis, treatment and also PANDAS’ variants.
In 1998, Sweedo realized that there were some children suffering with obsessive-compulsive symptomatology and also with tics. This was a group of kids completely different from the ones that had the primary diagnose of OCD and Tics Disorders, since in this group there seemed to be a rather abrupt onset of symptoms, which was still associated with a previous infection by group A Streptococcus. Intrigued with this, Sweedo decides to start a study to see if this was just a coincidence or if the infections led to the beginning of the symptoms. That’s how PANDAS was born, an acronym for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections. This article aims to approach in a concise and easily way all the evolution of PANDAS’ concept, the autoimmune pathophysiological basis, the diagnosis, treatment and also PANDAS’ variants.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2018
Palavras-chave
Pediatric autoimmune neuropsychiatric disorders Streptococcus Grupo A Autoimunidade Otorrinolaringologia