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An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers

2022Artigo científico Acesso aberto
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dc.contributor.authorMarciniak, Stephanie
dc.contributor.authorBergey, Christina M.
dc.contributor.authorSilva, Ana Maria
dc.contributor.authorHałuszko, Agata
dc.contributor.authorFurmanek, Mirosław
dc.contributor.authorVeselka, Barbara
dc.contributor.authorVelemínský, Petr
dc.contributor.authorVercellotti, Giuseppe
dc.contributor.authorWahl, Joachim
dc.contributor.authorZariņa, Gunita
dc.contributor.authorLonghi, Cristina
dc.contributor.authorKolář, Jan
dc.contributor.authorGarrido-Pena, Rafael
dc.contributor.authorFlores-Fernández, Raúl
dc.contributor.authorHerrero-Corral, Ana M.
dc.contributor.authorSimalcsik, Angela
dc.contributor.authorMüller, Werner
dc.contributor.authorSheridan, Alison
dc.contributor.authorMiliauskienė, Žydrūnė
dc.contributor.authorJankauskas, Rimantas
dc.contributor.authorMoiseyev, Vyacheslav
dc.contributor.authorKöhler, Kitti
dc.contributor.authorKirály, Ágnes
dc.contributor.authorGamarra, Beatriz
dc.contributor.authorCheronet, Olivia
dc.contributor.authorSzeverényi, Vajk
dc.contributor.authorKiss, Viktória
dc.contributor.authorSzeniczey, Tamás
dc.contributor.authorKiss, Krisztián
dc.contributor.authorZoffmann, Zsuzsanna K.
dc.contributor.authorKoós, Judit
dc.contributor.authorHellebrandt, Magdolna
dc.contributor.authorMaier, Robert M.
dc.contributor.authorDomboróczki, László
dc.contributor.authorVirag, Cristian
dc.contributor.authorNovak, Mario
dc.contributor.authorReich, David
dc.contributor.authorHajdu, Tamás
dc.contributor.authorvon Cramon-Taubadel, Noreen
dc.contributor.authorPinhasi, Ron
dc.contributor.authorPerry, George H.
dc.date.accessioned2023-03-29T11:27:21Z
dc.date.available2023-03-29T11:27:21Z
dc.date.issued2022
dc.description.abstractHuman culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared “predicted” genetic contributions to height from paleogenomic data and “achieved” adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (∼38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of −3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and −2.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals −2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarciniak, S., Bergey, C. M., Silva, A. M., Haluszko, A., Furmanek, M., Veselka, B., Veleminsky, P., Vercellotti, G., Wahl, J., Zarina, G., Longhi, C., Kolar, J., Garrido-Pena, R., Flores-Fernandez, R., Herrero-Corral, A. M., Simalcsik, A., Muller, W., Sheridan, A., Miliauskiene, Z., Jankauskas, R., Moiseyev, V., Kohler, K., Kiraly, A., Gamarra, B., Cheronet, O., Szeverenyi, V., Kiss, V., Szeniczey, T., Kiss, K., Zoffmann, Z. K., Koos, J., Hellebrandt, M., Maier, R. M., Domboroczki, L., Virag, C., Novak, M., Reich, D., Hajdu, T., von Cramon-Taubadel, N., Pinhasi, R., & Perry, G. H. (2022). An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmers. Proc Natl Acad Sci U S A, 119(15) e2106743119. doi: 10.1073/pnas.2106743119pt_PT
dc.identifier.doihttps://doi.org/10.1073/pnas.2106743119pt_PT
dc.identifier.eissn1091-6490
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/10451/56891
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencept_PT
dc.relationWenner-Gren Foundation Grant 222377pt_PT
dc.relationNIH Grant R01-GM115656pt_PT
dc.relationDKRVO/2019-2023/7.I.dpt_PT
dc.relationNational Museum, 00023272pt_PT
dc.relationRV67985939 of the Institute of Botany of the Czech Academy of Sciencespt_PT
dc.relationCzech Science Foundation Grant 19-20970Ypt_PT
dc.relationH2020-MSCA-IF-2015 -703373.pt_PT
dc.relationHungarian Research, Development and Innovation Office Project FK128013pt_PT
dc.relationHungarian Research, Development and Innovation Office Project K124326pt_PT
dc.relationCroatian Science Fund Grant HRZZ IP-2016-06-1450pt_PT
dc.relation.publisherversionhttps://www.pnas.org/doi/full/10.1073/pnas.2106743119pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPaleogenomicspt_PT
dc.subjectStature variationpt_PT
dc.subjectAgriculture transitionpt_PT
dc.subjectHealthpt_PT
dc.titleAn integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early european farmerspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue15pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume119pt_PT
person.familyNameSilva
person.givenNameAna Maria
person.identifier.ciencia-idF21D-4659-29AB
person.identifier.orcid0000-0002-1912-6581
person.identifier.ridE-6281-2015
person.identifier.scopus-author-id55939389400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2bd9c836-5465-4034-afd9-f3d50381488c
relation.isAuthorOfPublication.latestForDiscovery2bd9c836-5465-4034-afd9-f3d50381488c

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