Publicação
Protein-biomembrane interactions as therapeutic targets
| dc.contributor.author | Domingues, Marco M. | |
| dc.contributor.author | Matos, Pedro M. | |
| dc.contributor.author | Carvalho, Filomena A. | |
| dc.contributor.author | Santos, Nuno C. | |
| dc.date.accessioned | 2014-03-11T16:40:59Z | |
| dc.date.available | 2014-03-11T16:40:59Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Biological membranes are dynamic structures essential for several cellular phenomena. The scope of the work of the Institute of Molecular Medicine (IMM) Biomembranes Unit is the study of biochemical and biophysical processes occurring at the membrane level on human cells and on their viral and bacterial pathogens. On the viral context, we are primarily interested on HIV and dengue virus, and particularly on the two steps of their life cycle involving their interaction with host cell membranes: the viral entry into target cells and the assembly of new viral particles. A special focus will be given to the study of the role of biological membranes on the mechanism of action of the HIV entry (membrane fusion) inhibitors enfuvirtide and T-1249. We are also involved in assessing the molecular basis of the activity of microbicides, such as rBPI21, that bind to specific components of bacterial membranes. Additionally, our line of work on the binding of fibrinogen to erythrocytes, and its relevance as a cardiovascular risk factor will be presented. An approach to the latter problem by single-molecule force spectroscopy, using an atomic force microscope (AFM), allowed the molecular recognition, characterization and partial identification of the human erythrocyte receptor for fibrinogen. | eng |
| dc.description.sponsorship | These lines of work were supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal; projects PTDC/SAU-OSM/73449/2006 and PTDC/ QUI-BIQ/104787/2008), by the FP7-PEOPLE IRSES (International Research Staff Exchange Scheme) project MEMPEPACROSS (EU), and by Fundação Calouste Gulbenkian (Portugal). MMD and PMM also thank FCT-MCTES for the PhD fellowships SFRH/BD/41750/2007 and SFRH/BD/42205/2007, respectively. | eng |
| dc.identifier.citation | CanalBQ 4. n.º 8, Julho, 2011 | por |
| dc.identifier.issn | 1646-4192 | |
| dc.identifier.uri | http://canalbq.spb.pt/ | |
| dc.identifier.uri | http://hdl.handle.net/10451/10727 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Sociedade Portuguesa de Bioquímica | por |
| dc.title | Protein-biomembrane interactions as therapeutic targets | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 11 | por |
| oaire.citation.startPage | 4 | por |
| oaire.citation.title | Canal BQ - Revista da Sociedade Portuguesa de Bioquímica | por |
| oaire.citation.volume | 8 | por |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |