Effects of omega-3 and-6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice

Jordao, Luisa; Lengeling, Andreas; Bordat, Yann; Boudou, Frederic; Gicquel, Brigitte; Neyrolles, Olivier; Becker, Pablo D.; Guzman, Carlos A.; Griffiths, Gareth; Anes, Elsa

http://hdl.handle.net/10451/21583

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We recently showed that treatment of macrophages prior to Mycobacterium tuberculosis infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial killing whereas the anti - inflammatory, omega-3 lipid eicosapentaenoic acid (. - FCT ; FEDER [POCI/BIA-BCM/55327/2004, SFRWBD/14284/2003]. - We thank Cecilia Rodrigues, Maximilliano Gutierrez, Luis Mayorga and Sabrina Marion for their constructive support and discussion. This work was financed by FCT with co-participation of FEDER (POCI/BIA-BCM/55327/2004 and SFRWBD/14284/2003).