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Urinary Biomarkers and Point-of-Care Urinalysis Devices for Early Diagnosis and Management of Disease: A Review

2023Journal article Open access
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dc.contributor.authorSequeira-Antunes, Beatriz
dc.contributor.authorFerreira, Hugo Alexandre
dc.date.accessioned2025-03-13T17:50:17Z
dc.date.available2025-03-13T17:50:17Z
dc.date.issued2023
dc.description.abstractBiosensing and microfluidics technologies are transforming diagnostic medicine by accurately detecting biomolecules in biological samples. Urine is a promising biological fluid for diagnostics due to its noninvasive collection and wide range of diagnostic biomarkers. Point-of-care urinalysis, which integrates biosensing and microfluidics, has the potential to bring affordable and rapid diagnostics into the home to continuing monitoring, but challenges still remain. As such, this review aims to provide an overview of biomarkers that are or could be used to diagnose and monitor diseases, including cancer, cardiovascular diseases, kidney diseases, and neurodegenerative disorders, such as Alzheimer’s disease. Additionally, the different materials and techniques for the fabrication of microfluidic structures along with the biosensing technologies often used to detect and quantify biological molecules and organisms are reviewed. Ultimately, this review discusses the current state of point-of-care urinalysis devices and highlights the potential of these technologies to improve patient outcomes. Traditional point-of-care urinalysis devices require the manual collection of urine, which may be unpleasant, cumbersome, or prone to errors. To overcome this issue, the toilet itself can be used as an alternative specimen collection and urinalysis device. This review then presents several smart toilet systems and incorporated sanitary devices for this purpose.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biomedicines11041051pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/99313
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UIDB/00645/2020pt_PT
dc.relationFundação para a Ciência e a Tecnologia (FCT) grant number UIDP/00645/2020pt_PT
dc.relationExotictarget Lda.pt_PT
dc.subjecturine metabolitespt_PT
dc.subjectbiomarkerspt_PT
dc.subjectbiosensingpt_PT
dc.subjectmicrofluidicspt_PT
dc.subjecturinalysispt_PT
dc.subjectcontinuous monitoringpt_PT
dc.subjectnoninvasive health monitoringpt_PT
dc.titleUrinary Biomarkers and Point-of-Care Urinalysis Devices for Early Diagnosis and Management of Disease: A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage1051pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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