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Modulation of neuromuscular transmission using transcutaneous direct currents: an exploratory study

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dc.contributor.authorCaetano, Andre
dc.contributor.authorCarvalho, Mamede
dc.date.accessioned2021-12-09T16:17:32Z
dc.date.available2021-12-09T16:17:32Z
dc.date.issued2020
dc.description© 2020 Elsevier Masson SAS. All rights reserved.pt_PT
dc.description.abstractObjective: To assess the in vivo long-lasting effects on neuromuscular transmission using transcutaneous stimulation with anodal and cathodal direct currents applied over the end-plate region (epDCS). Methods: An active DCS electrode was placed over the end-plate region of both abductor pollicis brevis and first dorsal interosseous muscles, with a reference electrode located on the forearm. Cathodal or anodal currents were applied (2.5mA during 15min). Repetitive nerve stimulation of the median and ulnar nerves at the wrist was performed before and after DCS: protocol A - 500 stimuli at 3Hz; protocol B - 30 stimuli at 30Hz. For both muscles, we measured changes in amplitude and area between the first and 4th compound muscle action potential (CMAP) and between the first and 500th CMAP (protocol A); and the change in amplitude and area between the first and 30th CMAP (protocol B). Results: Anodal current did not change any measurement. Using cathodal epDCS and median nerve testing, there was a larger increase in CMAP amplitude (p=0.046) and a smaller decrease in area (p=0.008) between the first and 30th response (protocol B). Using cathodal epDCS and ulnar nerve testing, there was a possible significant smaller amplitude decrease of the CMAP measured, between the first and fourth response (protocol A). Conclusions: Cathodal transcutaneous direct currents over the end-plate may modulate end-plate function by increasing the release of quanta of acetylcholine (Ach) and/or the number of Ach receptors available. Future studies should address this topic.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurophysiol Clin. 2020 Oct;50(5):315-320pt_PT
dc.identifier.doi10.1016/j.neucli.2020.10.002pt_PT
dc.identifier.eissn1769-7131
dc.identifier.issn0987-7053
dc.identifier.urihttp://hdl.handle.net/10451/50318
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neurophysiologie-cliniquept_PT
dc.subjectDCSpt_PT
dc.subjectHigh-frequencypt_PT
dc.subjectLow-frequencypt_PT
dc.subjectModulationpt_PT
dc.subjectNeuromuscular transmissionpt_PT
dc.subjectRepetitive nerve stimulationpt_PT
dc.titleModulation of neuromuscular transmission using transcutaneous direct currents: an exploratory studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage320pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage315pt_PT
oaire.citation.titleNeurophysiologie Cliniquept_PT
oaire.citation.volume50pt_PT
person.familyNameCaetano
person.familyNamede Carvalho
person.givenNameAndre
person.givenNameMamede
person.identifier.orcid0000-0002-9040-5516
person.identifier.orcid0000-0001-7556-0158
person.identifier.scopus-author-id7101893769
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1d093004-e1d0-4cad-8c9e-a382b69b68f3
relation.isAuthorOfPublicationdd7f55d4-c2b5-4fd2-9bd1-a9542a62f58f
relation.isAuthorOfPublication.latestForDiscovery1d093004-e1d0-4cad-8c9e-a382b69b68f3

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