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Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man

2009Artigo científico Acesso restrito
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dc.contributor.authorBártolo, Inês
dc.contributor.authorCamacho, Ricardo
dc.contributor.authorBarroso, Helena
dc.contributor.authorBezerra, Victor
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2025-08-14T23:05:13Z
dc.date.available2025-08-14T23:05:13Z
dc.date.issued2009
dc.date.updated2023-02-03T14:43:42Z
dc.description.abstractSeronegative HIV-1 infection has important implications for diagnosis and prevention. We describe a case of HIV-1 infection without seroconversion and fast progression to AIDS and death. Genetic and phylogenetic analysis indicated that the patient was infected with a CRF14_BG-like strain selectively transmitted by his seropositive sexual partner. The results suggest a massive infection with a highly aggressive CRF14_BG-like strain and/or the presence of an unidentified immunological deficiency that has prevented the formation of HIV-1-specific antibodies.pt_PT
dc.description.sponsorshipThe clinical and laboratorial contributions of Manuela Mafra and Sandra Bento for the early identification and study of these patients are gratefully acknowledged. Author’s contributions: N.T., R.C., and V.B. designed the research. N.T., R.C., V.B., I.B. and H.B. performed the research, interpreted the data and wrote the paper. All authors reviewed and accepted the final manuscript. Financial Support: This work was supported by grant CRIA-CR3751 from Comissão Nacional de Luta Contra a SIDA, Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBártolo I, Camacho R, Barroso H, Bezerra V, Taveira N. Rapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young man. AIDS 2009;23:2359–62. https://doi.org/10.1097/QAD.0b013e328332d5e1.pt_PT
dc.identifier.doi10.1097/QAD.0b013e328332d5e1pt_PT
dc.identifier.eid2-s2.0-70449344717
dc.identifier.slugcv-prod-1108469
dc.identifier.urihttp://hdl.handle.net/10400.5/102929
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott / Wolters Kluwerpt_PT
dc.relation.publisherversionhttps://journals.lww.com/aidsonline/abstract/2009/11130/rapid_clinical_progression_to_aids_and_death_in_a.14.aspxpt_PT
dc.titleRapid clinical progression to AIDS and death in a persistently seronegative HIV-1 infected heterosexual young manpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2362pt_PT
oaire.citation.issue17pt_PT
oaire.citation.startPage2359pt_PT
oaire.citation.titleAIDSpt_PT
oaire.citation.volume23pt_PT
person.familyNameBártolo
person.familyNameTaveira
person.givenNameInês
person.givenNameNuno
person.identifier318426
person.identifier476379
person.identifier.ciencia-id661E-F5CB-F85A
person.identifier.ciencia-id7111-3383-A926
person.identifier.orcid0000-0002-2022-8921
person.identifier.orcid0000-0003-0176-5585
person.identifier.ridA-7477-2014
person.identifier.ridA-6252-2014
person.identifier.scopus-author-id8418824400
person.identifier.scopus-author-id6602731390
rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication17555d0a-4e10-49ce-b415-00fe51b57cfd
relation.isAuthorOfPublicationb57e2ea6-7336-4f8f-96a9-9ff4677829ee
relation.isAuthorOfPublication.latestForDiscoveryb57e2ea6-7336-4f8f-96a9-9ff4677829ee

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