Publicação
Rearranged jatrophane-type diterpenes from Euphorbia species. Evaluation of their effects on the reversal of multidrug resistance
| dc.contributor.author | Madureira, AM | |
| dc.contributor.author | Ferreira, MJU | |
| dc.contributor.author | Gyemant, N | |
| dc.contributor.author | Ugocsai, K | |
| dc.contributor.author | Ascenso, JR | |
| dc.contributor.author | Abreu, PM | |
| dc.contributor.author | Hohmann, J | |
| dc.contributor.author | Molnar, J | |
| dc.date.accessioned | 2015-12-30T10:17:06Z | |
| dc.date.available | 2015-12-30T10:17:06Z | |
| dc.date.issued | 2004 | |
| dc.description.abstract | The rearranged jatrophane-type diterpenes (1 - 3), isolated from the Me2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species. | |
| dc.format | application/pdf | |
| dc.identifier.citation | PLANTA MEDICA. - Vol. 70, n. 1 (JAN 2004), p. 45-49 | |
| dc.identifier.doi | http://dx.doi.org/10.1055/s-2004-815454 | |
| dc.identifier.issn | 0032-0943 | |
| dc.identifier.uri | http://hdl.handle.net/10451/20924 | |
| dc.language.iso | eng | |
| dc.publisher | GEORG THIEME VERLAG KG | |
| dc.subject | Plant Sciences | |
| dc.subject | Chemistry, Medicinal | |
| dc.subject | Pharmacology & Pharmacy | |
| dc.title | Rearranged jatrophane-type diterpenes from Euphorbia species. Evaluation of their effects on the reversal of multidrug resistance | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 49 | por |
| oaire.citation.startPage | 45 | por |
| oaire.citation.title | PLANTA MEDICA | por |
| oaire.citation.volume | Vol. 70 | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article |